Long-term remission after fetal liver transplantation in acute leukemia: a 30-year follow-up report of two cases
Abstract Fetal liver hematopoietic stem cells (HSCs) have the capacity to temporarily engraft, thereby facilitating the reconstitution of hematopoiesis without severe graft-versus-host disease (GVHD). In two cases of acute leukemia, the patients underwent fetal liver transplantation (FLT), receiving...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-024-04119-y |
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| author | Jing-wen Niu Jiangwei Hu Hu Chen Bin Zhang Liangding Hu |
| author_facet | Jing-wen Niu Jiangwei Hu Hu Chen Bin Zhang Liangding Hu |
| author_sort | Jing-wen Niu |
| collection | DOAJ |
| description | Abstract Fetal liver hematopoietic stem cells (HSCs) have the capacity to temporarily engraft, thereby facilitating the reconstitution of hematopoiesis without severe graft-versus-host disease (GVHD). In two cases of acute leukemia, the patients underwent fetal liver transplantation (FLT), receiving cells from multiple donors at doses ranging from 7.02 to 8.3 × 10^8 cells/kg, following an intensive conditioning regimen in 1983 and 1985. Remarkably, both individuals have since achieved sustained complete remission and hematopoietic recovery, and have maintained a normal life for over three decades. Although FLT is no longer a viable clinical option, the positive outcomes of these cases are noteworthy and are shared herein. Our findings underscore the potential of FLT to offer short-term hematopoietic support, contributing to the recovery of patients with acute leukemia and may inspire research into ideal HSCs that emulate the characteristics of fetal liver cells for future transplantation applications. |
| format | Article |
| id | doaj-art-441d2bbe70504f4f87ffe50dbe965177 |
| institution | DOAJ |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-441d2bbe70504f4f87ffe50dbe9651772025-08-20T02:48:11ZengBMCStem Cell Research & Therapy1757-65122025-02-011611510.1186/s13287-024-04119-yLong-term remission after fetal liver transplantation in acute leukemia: a 30-year follow-up report of two casesJing-wen Niu0Jiangwei Hu1Hu Chen2Bin Zhang3Liangding Hu4Senior Department of Hematology, the Fifth Medical Center of PLA General HospitalSenior Department of Hematology, the Fifth Medical Center of PLA General HospitalSenior Department of Hematology, the Fifth Medical Center of PLA General HospitalSenior Department of Hematology, the Fifth Medical Center of PLA General HospitalSenior Department of Hematology, the Fifth Medical Center of PLA General HospitalAbstract Fetal liver hematopoietic stem cells (HSCs) have the capacity to temporarily engraft, thereby facilitating the reconstitution of hematopoiesis without severe graft-versus-host disease (GVHD). In two cases of acute leukemia, the patients underwent fetal liver transplantation (FLT), receiving cells from multiple donors at doses ranging from 7.02 to 8.3 × 10^8 cells/kg, following an intensive conditioning regimen in 1983 and 1985. Remarkably, both individuals have since achieved sustained complete remission and hematopoietic recovery, and have maintained a normal life for over three decades. Although FLT is no longer a viable clinical option, the positive outcomes of these cases are noteworthy and are shared herein. Our findings underscore the potential of FLT to offer short-term hematopoietic support, contributing to the recovery of patients with acute leukemia and may inspire research into ideal HSCs that emulate the characteristics of fetal liver cells for future transplantation applications.https://doi.org/10.1186/s13287-024-04119-yFetal liver transplantation (FLT)Acute leukemiaHematopoietic stem cells (HSCs)Graft-versus-host disease (GVHD)Long-term remission |
| spellingShingle | Jing-wen Niu Jiangwei Hu Hu Chen Bin Zhang Liangding Hu Long-term remission after fetal liver transplantation in acute leukemia: a 30-year follow-up report of two cases Stem Cell Research & Therapy Fetal liver transplantation (FLT) Acute leukemia Hematopoietic stem cells (HSCs) Graft-versus-host disease (GVHD) Long-term remission |
| title | Long-term remission after fetal liver transplantation in acute leukemia: a 30-year follow-up report of two cases |
| title_full | Long-term remission after fetal liver transplantation in acute leukemia: a 30-year follow-up report of two cases |
| title_fullStr | Long-term remission after fetal liver transplantation in acute leukemia: a 30-year follow-up report of two cases |
| title_full_unstemmed | Long-term remission after fetal liver transplantation in acute leukemia: a 30-year follow-up report of two cases |
| title_short | Long-term remission after fetal liver transplantation in acute leukemia: a 30-year follow-up report of two cases |
| title_sort | long term remission after fetal liver transplantation in acute leukemia a 30 year follow up report of two cases |
| topic | Fetal liver transplantation (FLT) Acute leukemia Hematopoietic stem cells (HSCs) Graft-versus-host disease (GVHD) Long-term remission |
| url | https://doi.org/10.1186/s13287-024-04119-y |
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