Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast Thailand
Background and Aim. Risk factors for Helicobacter pylori infection are genetic susceptibility and poor living conditions. This study aimed to investigate the Mdm2 gene, clarithromycin resistance, and possible risk factors for Helicobacter pylori infection. Methods. Risk factors and clinical characte...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/9130602 |
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| author | Taweesak Tongtawee Soraya Kaewpitoon Natthawut Kaewpitoon Chavaboon Dechsukhum Wilairat Leeanansaksiri Ryan A. Loyd Likit Matrakool Sukij Panpimanmas |
| author_facet | Taweesak Tongtawee Soraya Kaewpitoon Natthawut Kaewpitoon Chavaboon Dechsukhum Wilairat Leeanansaksiri Ryan A. Loyd Likit Matrakool Sukij Panpimanmas |
| author_sort | Taweesak Tongtawee |
| collection | DOAJ |
| description | Background and Aim. Risk factors for Helicobacter pylori infection are genetic susceptibility and poor living conditions. This study aimed to investigate the Mdm2 gene, clarithromycin resistance, and possible risk factors for Helicobacter pylori infection. Methods. Risk factors and clinical characteristics were analyzed, including patient demographic data, patient income, personal history, possible source of transmission, patient symptoms, endoscopic findings, patterns of clarithromycin resistance, and patterns of Mdm2 SNIP309. Results. Ingestion of pickled fish (OR = 11.27, 95% CI = 4.31–29.45, p<0.0001), salt crab (OR = 8.83, 95% CI = 1.99–39.14, p<0.001), and Papaya salad (OR = 8.73, 95% CI = 4.54–16.79, p<0.01). The prevalence of clarithromycin resistance was 56% (wild type, A2143/2142A, is 23.8%; mutation, A2143/2142CG, is 35.7%; wild type + mutation is 40.5%). The genetic polymorphisms of Mdm2 SNIP309 were SNIP309 T/T homozygous in 78%, SNIP309 G/T heterozygous in 19%, and SNIP309 G/G homozygous in 3%. Conclusion. Pickled fish, salt crab, and Papaya salad are positive risk factors. There was high prevalence of clarithromycin resistance. The Mdm2 SNIP309 G/G homozygous genotype might be a risk factor for gastric cancer and the fact that it is infrequent in Thailand. |
| format | Article |
| id | doaj-art-44119bfd37904770aed29b577c901047 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-44119bfd37904770aed29b577c9010472025-02-03T01:22:23ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/91306029130602Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast ThailandTaweesak Tongtawee0Soraya Kaewpitoon1Natthawut Kaewpitoon2Chavaboon Dechsukhum3Wilairat Leeanansaksiri4Ryan A. Loyd5Likit Matrakool6Sukij Panpimanmas7Department of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, ThailandSuranaree University of Technology Hospital, Nakhon Ratchasima 30000, ThailandParasite Research Unit, Suranaree University of Technology, Nakhon Ratchasima 30000, ThailandSuranaree University of Technology Hospital, Nakhon Ratchasima 30000, ThailandSchool of Preclinic, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, ThailandSuranaree University of Technology Hospital, Nakhon Ratchasima 30000, ThailandDepartment of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, ThailandDepartment of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, ThailandBackground and Aim. Risk factors for Helicobacter pylori infection are genetic susceptibility and poor living conditions. This study aimed to investigate the Mdm2 gene, clarithromycin resistance, and possible risk factors for Helicobacter pylori infection. Methods. Risk factors and clinical characteristics were analyzed, including patient demographic data, patient income, personal history, possible source of transmission, patient symptoms, endoscopic findings, patterns of clarithromycin resistance, and patterns of Mdm2 SNIP309. Results. Ingestion of pickled fish (OR = 11.27, 95% CI = 4.31–29.45, p<0.0001), salt crab (OR = 8.83, 95% CI = 1.99–39.14, p<0.001), and Papaya salad (OR = 8.73, 95% CI = 4.54–16.79, p<0.01). The prevalence of clarithromycin resistance was 56% (wild type, A2143/2142A, is 23.8%; mutation, A2143/2142CG, is 35.7%; wild type + mutation is 40.5%). The genetic polymorphisms of Mdm2 SNIP309 were SNIP309 T/T homozygous in 78%, SNIP309 G/T heterozygous in 19%, and SNIP309 G/G homozygous in 3%. Conclusion. Pickled fish, salt crab, and Papaya salad are positive risk factors. There was high prevalence of clarithromycin resistance. The Mdm2 SNIP309 G/G homozygous genotype might be a risk factor for gastric cancer and the fact that it is infrequent in Thailand.http://dx.doi.org/10.1155/2016/9130602 |
| spellingShingle | Taweesak Tongtawee Soraya Kaewpitoon Natthawut Kaewpitoon Chavaboon Dechsukhum Wilairat Leeanansaksiri Ryan A. Loyd Likit Matrakool Sukij Panpimanmas Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast Thailand Gastroenterology Research and Practice |
| title | Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast Thailand |
| title_full | Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast Thailand |
| title_fullStr | Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast Thailand |
| title_full_unstemmed | Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast Thailand |
| title_short | Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast Thailand |
| title_sort | characteristics and risk factors of helicobacter pylori associated gastritis a prospective cross sectional study in northeast thailand |
| url | http://dx.doi.org/10.1155/2016/9130602 |
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