In situ and dynamic screening of extracellular vesicles as predictive biomarkers in immune-checkpoint inhibitor therapies

In situ and dynamic screening of extracellular vesicles as predictive biomarkers in immune-checkpoint inhibitor therapies

Abstract Extracellular vesicles (EVs) is promising in predicting the efficacy of immune checkpoint inhibitor (ICI) therapies. But it is challenging to determine the level of circulating EVs due to their variations in spatial and temporal distribution. To address this, we developed an in situ EV dete...

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Bibliographic Details
Main Authors: Yihe Wang, Yue Sun, Mengqi Liu, Chao Wang, Miao Huang, Jiaoyan Qiu, Ningkai Yang, Yu Zhang, Hong Liu, Lin Han
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
Extracellular vesicles
Tumor spheroids
Immune checkpoint inhibitors
PD-L1
Machine learning
Online Access:https://doi.org/10.1186/s12951-025-03467-y
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