cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia

cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia

Abstract Background Impairment of the inner blood-retinal barrier (iBRB) leads to various blinding diseases including diabetic retinopathy (DR). The cGAS-STING pathway has emerged as a driving force of cardiovascular destruction, but its impact on the neurovascular system is unclear. Here, we show t...

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Main Authors: Xiangyu Ge, Xingfei Zhu, Wei Liu, Mingsen Li, Zhaotian Zhang, Ming Zou, Mi Deng, Haifeng Cui, Ziqing Chen, Li Wang, Xuebin Hu, Rong Ju, Xiangcheng Tang, Xiaoyan Ding, Lili Gong
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-025-03391-w
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