Development of mRNA–lipid nanoparticle intrabodies against rickettsial infection

Development of mRNA–lipid nanoparticle intrabodies against rickettsial infection

Abstract Background Rickettsiosis is among the deadliest vector-borne infectious diseases worldwide, in part because rickettsiae replicate within human cells, where antibodies and most drugs cannot effectively reach this obligatory intracellular pathogen. Ehrlichia chaffeensis, an emerging rickettsi...

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Bibliographic Details
Main Authors: Qi Yan, Nan Duan, Mingqun Lin, Wenqing Zhang, Stephen Denton, Yichen Zhong, Yizhou Dong, Yasuko Rikihisa
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Biomedical Science
Subjects:
Ehrlichia chaffeensis
Rickettsia
Anti–Etf-2
Intrabody
Endosome
RAB5
Online Access:https://doi.org/10.1186/s12929-025-01171-5
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