Botulinum toxin type A and cervical dystonia: a seven-year follow-up
Most cases of cervical dystonia (CD) are idiopathic, and focal injections of botulinum toxin A (BoNT/A) are the treatment of choice. The objective of our study was to document the effects of long-term BoNT/A treatment in idiopathic CD patients. Fifty-eight patients with idiopathic CD were recruited...
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Thieme Revinter Publicações
2011-10-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000600004&lng=en&tlng=en |
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| author | Carlos Henrique F. Camargo Hélio Afonso G. Teive Nilson Becker Renato P. Munhoz Lineu César Werneck |
| author_facet | Carlos Henrique F. Camargo Hélio Afonso G. Teive Nilson Becker Renato P. Munhoz Lineu César Werneck |
| author_sort | Carlos Henrique F. Camargo |
| collection | DOAJ |
| description | Most cases of cervical dystonia (CD) are idiopathic, and focal injections of botulinum toxin A (BoNT/A) are the treatment of choice. The objective of our study was to document the effects of long-term BoNT/A treatment in idiopathic CD patients. Fifty-eight patients with idiopathic CD were recruited from March 2001 to May 2002. Twenty-eight of the subjects were available for reassessment after seven years. During this period, all had received regular treatment with BoNT/A injections. Clinical information about patients and the severity of CD (TWSTRS and VAPS) at baseline assessment (2001-2002) and follow-up (2008-2009) was compared. Significant motor improvement was detected based on TWSTRS scale scores, which were used to analyze clinical severity (19.6±6.6 and 17.7±4.8; p<0.05). There was no improvement in the severity of cervical pain (p=0.43). In conclusion, BoNT/A was a safe and effective long-term therapy for CD. |
| format | Article |
| id | doaj-art-43fba1b7368643feaeefca10d0060274 |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publishDate | 2011-10-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-43fba1b7368643feaeefca10d00602742025-08-20T03:36:02ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272011-10-0169574575010.1590/S0004-282X2011000600004S0004-282X2011000600004Botulinum toxin type A and cervical dystonia: a seven-year follow-upCarlos Henrique F. Camargo0Hélio Afonso G. Teive1Nilson Becker2Renato P. Munhoz3Lineu César Werneck4Universidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáMost cases of cervical dystonia (CD) are idiopathic, and focal injections of botulinum toxin A (BoNT/A) are the treatment of choice. The objective of our study was to document the effects of long-term BoNT/A treatment in idiopathic CD patients. Fifty-eight patients with idiopathic CD were recruited from March 2001 to May 2002. Twenty-eight of the subjects were available for reassessment after seven years. During this period, all had received regular treatment with BoNT/A injections. Clinical information about patients and the severity of CD (TWSTRS and VAPS) at baseline assessment (2001-2002) and follow-up (2008-2009) was compared. Significant motor improvement was detected based on TWSTRS scale scores, which were used to analyze clinical severity (19.6±6.6 and 17.7±4.8; p<0.05). There was no improvement in the severity of cervical pain (p=0.43). In conclusion, BoNT/A was a safe and effective long-term therapy for CD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000600004&lng=en&tlng=endistonia cervicaltoxina botulínicadisfagia |
| spellingShingle | Carlos Henrique F. Camargo Hélio Afonso G. Teive Nilson Becker Renato P. Munhoz Lineu César Werneck Botulinum toxin type A and cervical dystonia: a seven-year follow-up Arquivos de Neuro-Psiquiatria distonia cervical toxina botulínica disfagia |
| title | Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
| title_full | Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
| title_fullStr | Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
| title_full_unstemmed | Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
| title_short | Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
| title_sort | botulinum toxin type a and cervical dystonia a seven year follow up |
| topic | distonia cervical toxina botulínica disfagia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000600004&lng=en&tlng=en |
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