MGMT epimutations and risk of incident cancer of the colon, glioblastoma multiforme, and diffuse large B cell lymphomas

MGMT epimutations and risk of incident cancer of the colon, glioblastoma multiforme, and diffuse large B cell lymphomas

Abstract Background Constitutional BRCA1 epimutations (promoter hypermethylation) are associated with an elevated risk of triple-negative breast cancer and high-grade serous ovarian cancer. While MGMT epimutations are frequent in colon cancer, glioblastoma, and B-cell lymphoma, it remains unknown wh...

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Bibliographic Details
Main Authors: Oleksii Nikolaienko, Garnet L. Anderson, Rowan T. Chlebowski, Su Yon Jung, Holly R. Harris, Stian Knappskog, Per E. Lønning
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Clinical Epigenetics
Subjects:
Cancer risk
MGMT
Epimutation
Constitutional methylation
Colon cancer
Glioblastoma
Online Access:https://doi.org/10.1186/s13148-025-01835-x
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