Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature
Background. Methylphenidate (MPH) is widely used in treating children with attention-deficit-hyperactivity disorder. Hepatotoxicity is a rare phenomenon; only few cases are described with no liver failure. Case. We report on the case of a 12-year-old boy who received MPH for attention-deficit-hypera...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2015/437298 |
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| author | Hoi Y. Tong Carmen Díaz Elena Collantes Nicolás Medrano Alberto M. Borobia Paloma Jara Elena Ramírez |
| author_facet | Hoi Y. Tong Carmen Díaz Elena Collantes Nicolás Medrano Alberto M. Borobia Paloma Jara Elena Ramírez |
| author_sort | Hoi Y. Tong |
| collection | DOAJ |
| description | Background. Methylphenidate (MPH) is widely used in treating children with attention-deficit-hyperactivity disorder. Hepatotoxicity is a rare phenomenon; only few cases are described with no liver failure. Case. We report on the case of a 12-year-old boy who received MPH for attention-deficit-hyperactivity disorder. Two months later the patient presented with signs and symptoms of hepatitis and MPH was discontinued, showing progressive worsening and developing liver failure and a liver transplantation was required. Other causes of liver failure were ruled out and the liver biopsy was suggestive of drug toxicity. Discussion. One rare adverse reaction of MPH is hepatotoxicity. The review of the literature shows few cases of liver injury attributed to MPH; all of them recovered after withdrawing the treatment. The probable mechanism of liver injury was MPH direct toxicity to hepatocytes. In order to establish the diagnosis of MPH-induced liver injury, we used CIOMS/RUCAM scale that led to an assessment of “possible” relationship. This report provides the first published case of acute MPH-induced liver failure with successful hepatic transplantation. Conclusions. It is important to know that hepatotoxicity can occur in patients with MPH treatment and monitoring the liver’s function is highly recommended. |
| format | Article |
| id | doaj-art-43f0ab5b6d4747edb6471cc36bca6b93 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-43f0ab5b6d4747edb6471cc36bca6b932025-08-20T03:36:02ZengWileyCase Reports in Pediatrics2090-68032090-68112015-01-01201510.1155/2015/437298437298Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the LiteratureHoi Y. Tong0Carmen Díaz1Elena Collantes2Nicolás Medrano3Alberto M. Borobia4Paloma Jara5Elena Ramírez6Department of Clinical Pharmacology, Hospital Universitario La Paz, IdiPaz, School of Medicina, Universidad Autónoma de Madrid, Paseo de la Castellana 261, 28046 Madrid, SpainPediatric Hepatology Department, Hospital Universitario La Paz, IdiPaz, Paseo de la Castellana 261, 28046 Madrid, SpainPathological Anatomy Department, Hospital Universitario La Paz, IdiPaz, Paseo de la Castellana 261, 28046 Madrid, SpainDepartment of Clinical Pharmacology, Hospital Universitario La Paz, IdiPaz, School of Medicina, Universidad Autónoma de Madrid, Paseo de la Castellana 261, 28046 Madrid, SpainDepartment of Clinical Pharmacology, Hospital Universitario La Paz, IdiPaz, School of Medicina, Universidad Autónoma de Madrid, Paseo de la Castellana 261, 28046 Madrid, SpainPediatric Hepatology Department, Hospital Universitario La Paz, IdiPaz, Paseo de la Castellana 261, 28046 Madrid, SpainDepartment of Clinical Pharmacology, Hospital Universitario La Paz, IdiPaz, School of Medicina, Universidad Autónoma de Madrid, Paseo de la Castellana 261, 28046 Madrid, SpainBackground. Methylphenidate (MPH) is widely used in treating children with attention-deficit-hyperactivity disorder. Hepatotoxicity is a rare phenomenon; only few cases are described with no liver failure. Case. We report on the case of a 12-year-old boy who received MPH for attention-deficit-hyperactivity disorder. Two months later the patient presented with signs and symptoms of hepatitis and MPH was discontinued, showing progressive worsening and developing liver failure and a liver transplantation was required. Other causes of liver failure were ruled out and the liver biopsy was suggestive of drug toxicity. Discussion. One rare adverse reaction of MPH is hepatotoxicity. The review of the literature shows few cases of liver injury attributed to MPH; all of them recovered after withdrawing the treatment. The probable mechanism of liver injury was MPH direct toxicity to hepatocytes. In order to establish the diagnosis of MPH-induced liver injury, we used CIOMS/RUCAM scale that led to an assessment of “possible” relationship. This report provides the first published case of acute MPH-induced liver failure with successful hepatic transplantation. Conclusions. It is important to know that hepatotoxicity can occur in patients with MPH treatment and monitoring the liver’s function is highly recommended.http://dx.doi.org/10.1155/2015/437298 |
| spellingShingle | Hoi Y. Tong Carmen Díaz Elena Collantes Nicolás Medrano Alberto M. Borobia Paloma Jara Elena Ramírez Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature Case Reports in Pediatrics |
| title | Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature |
| title_full | Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature |
| title_fullStr | Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature |
| title_full_unstemmed | Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature |
| title_short | Liver Transplant in a Patient under Methylphenidate Therapy: A Case Report and Review of the Literature |
| title_sort | liver transplant in a patient under methylphenidate therapy a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2015/437298 |
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