Fractional Electrodamage in A549 Human Lung Cancer Cells
Fractional electrodamage in A549 human lung cancer cells was analyzed by introducing a non-integer order parameter to model the influence of electrical stimulation on cellular behavior. Numerical simulations were conducted to evaluate the conversion of electrical energy to heat within A549 cancer ce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Fractal and Fractional |
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| Online Access: | https://www.mdpi.com/2504-3110/9/1/34 |
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| author | Hilario Martines-Arano Jose Alberto Arano-Martinez Manuel Alejandro Mosso-Pani Alejandra Valdivia-Flores Martin Trejo-Valdez Blanca Estela García-Pérez Carlos Torres-Torres |
| author_facet | Hilario Martines-Arano Jose Alberto Arano-Martinez Manuel Alejandro Mosso-Pani Alejandra Valdivia-Flores Martin Trejo-Valdez Blanca Estela García-Pérez Carlos Torres-Torres |
| author_sort | Hilario Martines-Arano |
| collection | DOAJ |
| description | Fractional electrodamage in A549 human lung cancer cells was analyzed by introducing a non-integer order parameter to model the influence of electrical stimulation on cellular behavior. Numerical simulations were conducted to evaluate the conversion of electrical energy to heat within A549 cancer cells, emphasizing the electrocapacitive effects and electrical conductivity in modulating dielectric properties. Using the Riemann–Liouville fractional calculus framework, experimental results were accurately fitted, demonstrating the non-integer nature of electrodamage processes. The study identified a strong dependency of electrical behavior on frequency, revealing a critical role of fractional dynamics in the dielectric breakdown and susceptibility of A549 cells to voltage changes. These findings advance our understanding of cellular responses to electrical fields and provide insights into applications in cancer diagnostics, monitoring, and potential therapeutic treatments. |
| format | Article |
| id | doaj-art-43e7c941e4bd4349882071b3e2b398d7 |
| institution | Kabale University |
| issn | 2504-3110 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fractal and Fractional |
| spelling | doaj-art-43e7c941e4bd4349882071b3e2b398d72025-01-24T13:33:26ZengMDPI AGFractal and Fractional2504-31102025-01-01913410.3390/fractalfract9010034Fractional Electrodamage in A549 Human Lung Cancer CellsHilario Martines-Arano0Jose Alberto Arano-Martinez1Manuel Alejandro Mosso-Pani2Alejandra Valdivia-Flores3Martin Trejo-Valdez4Blanca Estela García-Pérez5Carlos Torres-Torres6Escuela Superior Tepeji del Río, Universidad Autónoma del Estado de Hidalgo, Tepeji del Río de Ocampo 42860, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Ingeniería Mecánica y Eléctrica Unidad Zacatenco, Instituto Politécnico Nacional, Ciudad de México 07738, MexicoDepartamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoDepartamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoEscuela Superior de Ingeniería Química e Industrias Extractivas, Instituto Politécnico Nacional, Ciudad de México 07738, MexicoDepartamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Ingeniería Mecánica y Eléctrica Unidad Zacatenco, Instituto Politécnico Nacional, Ciudad de México 07738, MexicoFractional electrodamage in A549 human lung cancer cells was analyzed by introducing a non-integer order parameter to model the influence of electrical stimulation on cellular behavior. Numerical simulations were conducted to evaluate the conversion of electrical energy to heat within A549 cancer cells, emphasizing the electrocapacitive effects and electrical conductivity in modulating dielectric properties. Using the Riemann–Liouville fractional calculus framework, experimental results were accurately fitted, demonstrating the non-integer nature of electrodamage processes. The study identified a strong dependency of electrical behavior on frequency, revealing a critical role of fractional dynamics in the dielectric breakdown and susceptibility of A549 cells to voltage changes. These findings advance our understanding of cellular responses to electrical fields and provide insights into applications in cancer diagnostics, monitoring, and potential therapeutic treatments.https://www.mdpi.com/2504-3110/9/1/34A549 cellsfractional calculusfractional electrodamagebiological cells capacitanceelectrical tolerance threshold |
| spellingShingle | Hilario Martines-Arano Jose Alberto Arano-Martinez Manuel Alejandro Mosso-Pani Alejandra Valdivia-Flores Martin Trejo-Valdez Blanca Estela García-Pérez Carlos Torres-Torres Fractional Electrodamage in A549 Human Lung Cancer Cells Fractal and Fractional A549 cells fractional calculus fractional electrodamage biological cells capacitance electrical tolerance threshold |
| title | Fractional Electrodamage in A549 Human Lung Cancer Cells |
| title_full | Fractional Electrodamage in A549 Human Lung Cancer Cells |
| title_fullStr | Fractional Electrodamage in A549 Human Lung Cancer Cells |
| title_full_unstemmed | Fractional Electrodamage in A549 Human Lung Cancer Cells |
| title_short | Fractional Electrodamage in A549 Human Lung Cancer Cells |
| title_sort | fractional electrodamage in a549 human lung cancer cells |
| topic | A549 cells fractional calculus fractional electrodamage biological cells capacitance electrical tolerance threshold |
| url | https://www.mdpi.com/2504-3110/9/1/34 |
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