479 Effects of extracellular matrix on pacemaking cardiomyocyte function
Objectives/Goals: The extracellular matrix (ECM) of the sinoatrial node (SAN) is critical for maintaining automaticity in hiPSC-derived pacemaking cardiomyocytes (PCMs) under cyclic strain. We aim to determine the ECM ligands responsible for cell-ECM mediated mechanotransduction and the resulting ph...
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| Main Authors: | Brian Howard, Regan Smithers, Kaitlin Van Brusselen, Hillary K.J. Kao, Deborah K. Lieu |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2025-04-01
|
| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866124010707/type/journal_article |
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