479 Effects of extracellular matrix on pacemaking cardiomyocyte function

Objectives/Goals: The extracellular matrix (ECM) of the sinoatrial node (SAN) is critical for maintaining automaticity in hiPSC-derived pacemaking cardiomyocytes (PCMs) under cyclic strain. We aim to determine the ECM ligands responsible for cell-ECM mediated mechanotransduction and the resulting ph...

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Bibliographic Details
Main Authors: Brian Howard, Regan Smithers, Kaitlin Van Brusselen, Hillary K.J. Kao, Deborah K. Lieu
Format: Article
Language:English
Published: Cambridge University Press 2025-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866124010707/type/journal_article
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