Diagnosis delays associated with mortality among patients with haemorrhagic fever in Upper Southern Thailand: A hospital-based case control study
Objective: To investigate the association between diagnosis delays and mortality in patients with haemorrhagic fever in Upper Southern Thailand. Methods: A hospital-based case control study was conducted between December 2019 and January 2020. Cases were defined as patients who had been diagnosed wi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
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| Online Access: | https://journals.lww.com/10.4103/apjtm.apjtm_584_24 |
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| author | Siraphat Chokumnuaysit Somkiattiyos Woradet Bhunyabhadh Chaimay |
| author_facet | Siraphat Chokumnuaysit Somkiattiyos Woradet Bhunyabhadh Chaimay |
| author_sort | Siraphat Chokumnuaysit |
| collection | DOAJ |
| description | Objective:
To investigate the association between diagnosis delays and mortality in patients with haemorrhagic fever in Upper Southern Thailand.
Methods:
A hospital-based case control study was conducted between December 2019 and January 2020. Cases were defined as patients who had been diagnosed with haemorrhagic fever and died during hospitalization, while controls were patients with similar conditions who survived. Medical records were retrospectively reviewed, with the primary variable being a diagnosis delay of more than three days after the onset of illness. The outcome of interest was mortality during hospitalization. Data analysis involved descriptive statistics and multiple logistic regression.
Results:
A total of 38815 haemorrhagic fever cases were reported from 2014 to 2019. The case-to-control ratio was 1:3, comprising 66 cases and 198 controls. Among 66 cases and 198 controls, the median (IQR) time from illness onset to diagnosis was 4 (4) days in cases vs. 1 (0) day in controls. Diagnosis delays significantly increased mortality risk [adjusted OR (aOR) 5.60, 95% CI 2.74-11.46]. Other risk factors for mortality included age ≤5 years (aOR 16.15, 95% CI 3.70-70.42) and overweight status (aOR 3.43, 95% CI 1.57-7.52).
Conclusions:
Delayed diagnosis in patients with haemorrhagic fever was strongly associated with higher mortality rates. These findings highlight the critical importance of early diagnosis to reduce mortality in haemorrhagic fever cases. |
| format | Article |
| id | doaj-art-43dfac19ffc04a7cba4d7b2e53c9d0e8 |
| institution | DOAJ |
| issn | 2352-4146 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj-art-43dfac19ffc04a7cba4d7b2e53c9d0e82025-08-20T03:07:10ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462025-01-0118312213010.4103/apjtm.apjtm_584_24Diagnosis delays associated with mortality among patients with haemorrhagic fever in Upper Southern Thailand: A hospital-based case control studySiraphat ChokumnuaysitSomkiattiyos WoradetBhunyabhadh ChaimayObjective: To investigate the association between diagnosis delays and mortality in patients with haemorrhagic fever in Upper Southern Thailand. Methods: A hospital-based case control study was conducted between December 2019 and January 2020. Cases were defined as patients who had been diagnosed with haemorrhagic fever and died during hospitalization, while controls were patients with similar conditions who survived. Medical records were retrospectively reviewed, with the primary variable being a diagnosis delay of more than three days after the onset of illness. The outcome of interest was mortality during hospitalization. Data analysis involved descriptive statistics and multiple logistic regression. Results: A total of 38815 haemorrhagic fever cases were reported from 2014 to 2019. The case-to-control ratio was 1:3, comprising 66 cases and 198 controls. Among 66 cases and 198 controls, the median (IQR) time from illness onset to diagnosis was 4 (4) days in cases vs. 1 (0) day in controls. Diagnosis delays significantly increased mortality risk [adjusted OR (aOR) 5.60, 95% CI 2.74-11.46]. Other risk factors for mortality included age ≤5 years (aOR 16.15, 95% CI 3.70-70.42) and overweight status (aOR 3.43, 95% CI 1.57-7.52). Conclusions: Delayed diagnosis in patients with haemorrhagic fever was strongly associated with higher mortality rates. These findings highlight the critical importance of early diagnosis to reduce mortality in haemorrhagic fever cases.https://journals.lww.com/10.4103/apjtm.apjtm_584_24diagnosis delaysmortalityhaemorrhagic feverdengue haemorrhagic feverdengue shock syndrome |
| spellingShingle | Siraphat Chokumnuaysit Somkiattiyos Woradet Bhunyabhadh Chaimay Diagnosis delays associated with mortality among patients with haemorrhagic fever in Upper Southern Thailand: A hospital-based case control study Asian Pacific Journal of Tropical Medicine diagnosis delays mortality haemorrhagic fever dengue haemorrhagic fever dengue shock syndrome |
| title | Diagnosis delays associated with mortality among patients with haemorrhagic fever in Upper Southern Thailand: A hospital-based case control study |
| title_full | Diagnosis delays associated with mortality among patients with haemorrhagic fever in Upper Southern Thailand: A hospital-based case control study |
| title_fullStr | Diagnosis delays associated with mortality among patients with haemorrhagic fever in Upper Southern Thailand: A hospital-based case control study |
| title_full_unstemmed | Diagnosis delays associated with mortality among patients with haemorrhagic fever in Upper Southern Thailand: A hospital-based case control study |
| title_short | Diagnosis delays associated with mortality among patients with haemorrhagic fever in Upper Southern Thailand: A hospital-based case control study |
| title_sort | diagnosis delays associated with mortality among patients with haemorrhagic fever in upper southern thailand a hospital based case control study |
| topic | diagnosis delays mortality haemorrhagic fever dengue haemorrhagic fever dengue shock syndrome |
| url | https://journals.lww.com/10.4103/apjtm.apjtm_584_24 |
| work_keys_str_mv | AT siraphatchokumnuaysit diagnosisdelaysassociatedwithmortalityamongpatientswithhaemorrhagicfeverinuppersouthernthailandahospitalbasedcasecontrolstudy AT somkiattiyosworadet diagnosisdelaysassociatedwithmortalityamongpatientswithhaemorrhagicfeverinuppersouthernthailandahospitalbasedcasecontrolstudy AT bhunyabhadhchaimay diagnosisdelaysassociatedwithmortalityamongpatientswithhaemorrhagicfeverinuppersouthernthailandahospitalbasedcasecontrolstudy |