The renoprotective effects of tadalafil on ischemia–reperfusion injury during partial nephrectomy in an animal model

The renoprotective effects of tadalafil on ischemia–reperfusion injury during partial nephrectomy in an animal model

Abstract Background Although 25 min is the reported safe partial nephrectomy time for warm ischemia, acute kidney injury occurs even with arterial ligation within 25 min, causing serious complications in patients with chronic renal disease. Various drugs have been studied but evidence of their effec...

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Main Authors: Eun Hye Lee, Eun Sang Yoo, Bo Hyun Yoon, Minji Jeon, Tae Gyun Kwon, Bum Soo Kim, Yun-Sok Ha, Man-Hoon Han, Phil Hyun Song, Jae-Wook Chung
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Nephrology
Subjects:
Partial nephrectomy
Ischemic–reperfusion injury
Tadalafil
Online Access:https://doi.org/10.1186/s12882-025-04265-2
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