Research hotspots and trends on NF-κB in cognitive impairment: a bibliometric analysis
BackgroundCognitive impairment (CI) endangers the physical and mental health of patients in a significant manner, and it is expected that the number of people with CI in China will rise to 45.33 million by 2050. Therefore, CI has become a popular research topic. Inflammatory damage plays a key role...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1432455/full |
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| author | Lin Bai Lin Bai Fangyuan Xu Peijia Hu Peijia Hu Zhiqiang Shen Zhiqiang Shen Su Xingxing Su Xingxing Qingqing Wang Qingqing Wang Hongliang Cheng Hongliang Cheng |
| author_facet | Lin Bai Lin Bai Fangyuan Xu Peijia Hu Peijia Hu Zhiqiang Shen Zhiqiang Shen Su Xingxing Su Xingxing Qingqing Wang Qingqing Wang Hongliang Cheng Hongliang Cheng |
| author_sort | Lin Bai |
| collection | DOAJ |
| description | BackgroundCognitive impairment (CI) endangers the physical and mental health of patients in a significant manner, and it is expected that the number of people with CI in China will rise to 45.33 million by 2050. Therefore, CI has become a popular research topic. Inflammatory damage plays a key role in the pathogenesis of CI, and NF-κB is an important inflammatory signaling pathway. However, no bibliometric analysis regarding the relationship between CI and NF-κB has been reported.MethodsA bibliometric analysis regarding NF-κB and CI from 1 January 2008 to 12 December 2023 was conducted in the Science Citation Index-Expanded of the Web of Science Core Collection. The frontiers, hotspots, and trends of research regarding the role of NF-κB in CI were identified. VOSviewer and CiteSpace were used to analyze the retrieved articles and identify the author, country, institution, and keywords, as well as co-cited authors, co-cited journals, and co-cited references.ResultsWe analyzed 1,468 original articles and reviews. Publications on NF-κB in CI began in 2010 and increased sharply in 2018. Hong Hao was the most represented author, having published 19 articles, and Chinese authors published more studies than those from other countries. China Pharmaceutical University published the most papers; however, the United States has a strong influence and demonstrates international cooperation. The keywords “apolipoprotein e” and “therapeutic target” demonstrated strong citation bursts, and this tendency may persist in the upcoming years. Neuroinflammation demonstrated a strong influence in research regarding NF-κB in CI. Gut microbiota and ketogenic diet also play an important role in NF-κB in CI.ConclusionThis bibliometric analysis and visualization using VOSviewer and CiteSpace revealed that the role of NF-κB in CI has become a research hotspot. The results of this study indicated that “neuroinflammation,” “microglial,” and “pathway” remain hotspots for future research. However, studies regarding NF-κB in CI have predominantly focussed on basic research; future research should include therapeutic targets, microbiota, and ketogenic diet. |
| format | Article |
| id | doaj-art-43d3f2cfcd25411289124cfa749b48b5 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-43d3f2cfcd25411289124cfa749b48b52025-08-20T02:38:19ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-12-011110.3389/fmed.2024.14324551432455Research hotspots and trends on NF-κB in cognitive impairment: a bibliometric analysisLin Bai0Lin Bai1Fangyuan Xu2Peijia Hu3Peijia Hu4Zhiqiang Shen5Zhiqiang Shen6Su Xingxing7Su Xingxing8Qingqing Wang9Qingqing Wang10Hongliang Cheng11Hongliang Cheng12The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaAnhui University of Chinese Medicine, Hefei, ChinaAnhui University of Chinese Medicine, Hefei, ChinaThe Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaAnhui University of Chinese Medicine, Hefei, ChinaThe Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaAnhui University of Chinese Medicine, Hefei, ChinaThe Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaAnhui University of Chinese Medicine, Hefei, ChinaThe Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaAnhui University of Chinese Medicine, Hefei, ChinaThe Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaAnhui University of Chinese Medicine, Hefei, ChinaBackgroundCognitive impairment (CI) endangers the physical and mental health of patients in a significant manner, and it is expected that the number of people with CI in China will rise to 45.33 million by 2050. Therefore, CI has become a popular research topic. Inflammatory damage plays a key role in the pathogenesis of CI, and NF-κB is an important inflammatory signaling pathway. However, no bibliometric analysis regarding the relationship between CI and NF-κB has been reported.MethodsA bibliometric analysis regarding NF-κB and CI from 1 January 2008 to 12 December 2023 was conducted in the Science Citation Index-Expanded of the Web of Science Core Collection. The frontiers, hotspots, and trends of research regarding the role of NF-κB in CI were identified. VOSviewer and CiteSpace were used to analyze the retrieved articles and identify the author, country, institution, and keywords, as well as co-cited authors, co-cited journals, and co-cited references.ResultsWe analyzed 1,468 original articles and reviews. Publications on NF-κB in CI began in 2010 and increased sharply in 2018. Hong Hao was the most represented author, having published 19 articles, and Chinese authors published more studies than those from other countries. China Pharmaceutical University published the most papers; however, the United States has a strong influence and demonstrates international cooperation. The keywords “apolipoprotein e” and “therapeutic target” demonstrated strong citation bursts, and this tendency may persist in the upcoming years. Neuroinflammation demonstrated a strong influence in research regarding NF-κB in CI. Gut microbiota and ketogenic diet also play an important role in NF-κB in CI.ConclusionThis bibliometric analysis and visualization using VOSviewer and CiteSpace revealed that the role of NF-κB in CI has become a research hotspot. The results of this study indicated that “neuroinflammation,” “microglial,” and “pathway” remain hotspots for future research. However, studies regarding NF-κB in CI have predominantly focussed on basic research; future research should include therapeutic targets, microbiota, and ketogenic diet.https://www.frontiersin.org/articles/10.3389/fmed.2024.1432455/fullNF-κBcognitive impairmentbibliometric analysisCiteSpaceVOSviewer |
| spellingShingle | Lin Bai Lin Bai Fangyuan Xu Peijia Hu Peijia Hu Zhiqiang Shen Zhiqiang Shen Su Xingxing Su Xingxing Qingqing Wang Qingqing Wang Hongliang Cheng Hongliang Cheng Research hotspots and trends on NF-κB in cognitive impairment: a bibliometric analysis Frontiers in Medicine NF-κB cognitive impairment bibliometric analysis CiteSpace VOSviewer |
| title | Research hotspots and trends on NF-κB in cognitive impairment: a bibliometric analysis |
| title_full | Research hotspots and trends on NF-κB in cognitive impairment: a bibliometric analysis |
| title_fullStr | Research hotspots and trends on NF-κB in cognitive impairment: a bibliometric analysis |
| title_full_unstemmed | Research hotspots and trends on NF-κB in cognitive impairment: a bibliometric analysis |
| title_short | Research hotspots and trends on NF-κB in cognitive impairment: a bibliometric analysis |
| title_sort | research hotspots and trends on nf κb in cognitive impairment a bibliometric analysis |
| topic | NF-κB cognitive impairment bibliometric analysis CiteSpace VOSviewer |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1432455/full |
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