Impact of premature ovarian failure on mortality and morbidity among Chinese women.
<h4>Objective</h4>To evaluate associations of premature ovarian failure (POF) with mortality and morbidity in Asian populations.<h4>Methods</h4>We identified 1,003 cases of POF among 36,402 postmenopausal women who participated in the Shanghai Women's Health Study, a pop...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089597&type=printable |
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| Summary: | <h4>Objective</h4>To evaluate associations of premature ovarian failure (POF) with mortality and morbidity in Asian populations.<h4>Methods</h4>We identified 1,003 cases of POF among 36,402 postmenopausal women who participated in the Shanghai Women's Health Study, a population-based cohort study. Cox regression and logistic regression models were applied in data analysis.<h4>Results</h4>After adjustment for potential confounding factors, we found that POF increased the risk of total and cancer-specific mortality (HR (95%CIs): 1.29 (1.08-1.54) and 1.38 (1.05-1.81), respectively). POF was also associated with high prevalence of autoimmune disease (OR (95%CI): 1.56 (1.04-2.35)) but decreased incidence of breast cancer (OR (95%CI): 0.59 (0.38-0.91)). Similar results were observed when hormone replacement therapy users were excluded from the analysis. POF is associated with high waist-to-hip ratio.<h4>Conclusions</h4>Our results suggest that women with POF experience increased mortality and that these women may benefit from heightened surveillance and appropriate interventions. |
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| ISSN: | 1932-6203 |