Tumor treating fields: a new treatment for glioblastoma
Glioblastoma (GBM) is a fatal type of brain tumour. According to the World Health Organization (WHO) classification of 2021, GBMs have WHO grade 4 and are usually associated with a poor prognosis. Since GBMs show a pronounced infiltrative growth, a cure by complete resection of the tumor is unfortun...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-03-01
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| Series: | Biotechnology & Biotechnological Equipment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13102818.2022.2155567 |
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| author | Dimitar Slavkov Asen Hadzhiyanev Svetoslava Slavkova |
| author_facet | Dimitar Slavkov Asen Hadzhiyanev Svetoslava Slavkova |
| author_sort | Dimitar Slavkov |
| collection | DOAJ |
| description | Glioblastoma (GBM) is a fatal type of brain tumour. According to the World Health Organization (WHO) classification of 2021, GBMs have WHO grade 4 and are usually associated with a poor prognosis. Since GBMs show a pronounced infiltrative growth, a cure by complete resection of the tumor is unfortunately not possible. Both systemic and locoregional therapy methods are traditionally used and tested to improve the prognosis. A new method that is intended to prolong the progression-free survival is using electromagnetic alternating fields, the so-called tumor treating fields (TTF). This method is based on alternating electrical fields that act on the shaved scalp. The aim is to disrupt cell division and organization of cell organelles. In this review, we discuss the mechanism of TTF, summarize the results of our comprehensive literature search, and discuss potential of this new anti-cancer treatment modality. |
| format | Article |
| id | doaj-art-43cf0fac9a7141e89190ac77149a784b |
| institution | OA Journals |
| issn | 1310-2818 1314-3530 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Biotechnology & Biotechnological Equipment |
| spelling | doaj-art-43cf0fac9a7141e89190ac77149a784b2025-08-20T02:23:41ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302023-03-01371586310.1080/13102818.2022.2155567Tumor treating fields: a new treatment for glioblastomaDimitar Slavkov0Asen Hadzhiyanev1Svetoslava Slavkova2Clinic for Neurosurgery, Spine Surgery and Neuromodulation, HELIOS Vogtland-Klinikum Plauen GmbH, Plauen, GermanyDepartment of Neurosurgery, University Hospital ‘St. Ivan Rilsky’, Medical University of Sofia, Sofia, BulgariaClinic for Dermatology, HELIOS Vogtland-Klinikum Plauen GmbH, Plauen, GermanyGlioblastoma (GBM) is a fatal type of brain tumour. According to the World Health Organization (WHO) classification of 2021, GBMs have WHO grade 4 and are usually associated with a poor prognosis. Since GBMs show a pronounced infiltrative growth, a cure by complete resection of the tumor is unfortunately not possible. Both systemic and locoregional therapy methods are traditionally used and tested to improve the prognosis. A new method that is intended to prolong the progression-free survival is using electromagnetic alternating fields, the so-called tumor treating fields (TTF). This method is based on alternating electrical fields that act on the shaved scalp. The aim is to disrupt cell division and organization of cell organelles. In this review, we discuss the mechanism of TTF, summarize the results of our comprehensive literature search, and discuss potential of this new anti-cancer treatment modality.https://www.tandfonline.com/doi/10.1080/13102818.2022.2155567glioblastomatherapytumor treating fieldsTTF |
| spellingShingle | Dimitar Slavkov Asen Hadzhiyanev Svetoslava Slavkova Tumor treating fields: a new treatment for glioblastoma Biotechnology & Biotechnological Equipment glioblastoma therapy tumor treating fields TTF |
| title | Tumor treating fields: a new treatment for glioblastoma |
| title_full | Tumor treating fields: a new treatment for glioblastoma |
| title_fullStr | Tumor treating fields: a new treatment for glioblastoma |
| title_full_unstemmed | Tumor treating fields: a new treatment for glioblastoma |
| title_short | Tumor treating fields: a new treatment for glioblastoma |
| title_sort | tumor treating fields a new treatment for glioblastoma |
| topic | glioblastoma therapy tumor treating fields TTF |
| url | https://www.tandfonline.com/doi/10.1080/13102818.2022.2155567 |
| work_keys_str_mv | AT dimitarslavkov tumortreatingfieldsanewtreatmentforglioblastoma AT asenhadzhiyanev tumortreatingfieldsanewtreatmentforglioblastoma AT svetoslavaslavkova tumortreatingfieldsanewtreatmentforglioblastoma |