The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review
The health-promoting, preventive, protective, and therapeutic applications of the natural compound sulforaphane (SF) produced from its biogenic precursor in broccoli, glucoraphanin, are extremely well established. SF has been the subject of thousands of studies and over 125 clinical trials. The many...
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2025-01-01
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| author | Jed W. Fahey Mirran Raphaely |
| author_facet | Jed W. Fahey Mirran Raphaely |
| author_sort | Jed W. Fahey |
| collection | DOAJ |
| description | The health-promoting, preventive, protective, and therapeutic applications of the natural compound sulforaphane (SF) produced from its biogenic precursor in broccoli, glucoraphanin, are extremely well established. SF has been the subject of thousands of studies and over 125 clinical trials. The many mechanisms of action of SF in mammalian systems have been extensively documented. SF is the most potent naturally occurring inducer of the Keap1/Nrf2 pathway, which is most well-known for its upregulation of antioxidant and detoxification mechanisms and activation of pathways resulting in the inhibition of inflammation. Much of this regulation involves the various hormonal axes of the body. However, the influence of SF on hormone-mediated health conditions remains unexplored in recent scholarly reviews. This review aims to address this gap by exploring many of these interactions, with a focus on the health and wellness issues specific to both females and males. |
| format | Article |
| id | doaj-art-43cd922d33694881b6f36a472c793c8e |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj-art-43cd922d33694881b6f36a472c793c8e2025-01-24T13:19:41ZengMDPI AGApplied Sciences2076-34172025-01-0115252210.3390/app15020522The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive ReviewJed W. Fahey0Mirran Raphaely1Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAFlorandii, Monte Rio, CA 95462, USAThe health-promoting, preventive, protective, and therapeutic applications of the natural compound sulforaphane (SF) produced from its biogenic precursor in broccoli, glucoraphanin, are extremely well established. SF has been the subject of thousands of studies and over 125 clinical trials. The many mechanisms of action of SF in mammalian systems have been extensively documented. SF is the most potent naturally occurring inducer of the Keap1/Nrf2 pathway, which is most well-known for its upregulation of antioxidant and detoxification mechanisms and activation of pathways resulting in the inhibition of inflammation. Much of this regulation involves the various hormonal axes of the body. However, the influence of SF on hormone-mediated health conditions remains unexplored in recent scholarly reviews. This review aims to address this gap by exploring many of these interactions, with a focus on the health and wellness issues specific to both females and males.https://www.mdpi.com/2076-3417/15/2/522glucosinolatepreventionphytonutrientbioactiveisothiocyanatenutrition |
| spellingShingle | Jed W. Fahey Mirran Raphaely The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review Applied Sciences glucosinolate prevention phytonutrient bioactive isothiocyanate nutrition |
| title | The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review |
| title_full | The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review |
| title_fullStr | The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review |
| title_full_unstemmed | The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review |
| title_short | The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review |
| title_sort | impact of sulforaphane on sex specific conditions and hormone balance a comprehensive review |
| topic | glucosinolate prevention phytonutrient bioactive isothiocyanate nutrition |
| url | https://www.mdpi.com/2076-3417/15/2/522 |
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