The effect of beet leaf (Beta vulgaris) extract on learning and memory after cerebral ischemic reperfusion in rats
Background and aims: Cerebral ischemia causes tissue oxidative damage and leads to cell death. Antioxidants can reduce the adverse effects of ischemia in the brain. This study was conducted to determine the effect of Beta vulgaris hydroalcoholic extract on learning and memory caused by transient...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahrekord University of Medical Sciences
2024-12-01
|
| Series: | Future Natural Products |
| Subjects: | |
| Online Access: | http://fnp.skums.ac.ir/Article/fnp-165 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841543681170997248 |
|---|---|
| author | Kobra Mirahmadi Najmeh Asgharzadeh Zahra Lorigooini Marzieh Mardani Zahra Rabiei Diana Shahrani Mohamad Shahrani Mehrdad Shahrani Korrani |
| author_facet | Kobra Mirahmadi Najmeh Asgharzadeh Zahra Lorigooini Marzieh Mardani Zahra Rabiei Diana Shahrani Mohamad Shahrani Mehrdad Shahrani Korrani |
| author_sort | Kobra Mirahmadi |
| collection | DOAJ |
| description | Background and aims: Cerebral ischemia causes tissue oxidative damage and leads to cell death.
Antioxidants can reduce the adverse effects of ischemia in the brain. This study was conducted
to determine the effect of Beta vulgaris hydroalcoholic extract on learning and memory caused
by transient cerebral ischemia.
Methods: After preparing the herbal extract, the rats were divided into six groups: control, sham,
ischemia, and 3 ischemic groups that received the extract. Ischemia was induced by bilateral
carotid artery occlusion for 30 minutes. The control, sham, and ischemia groups received normal
saline for two weeks. Three treatment groups received 50, 100, and 200 mg/kg B. vulgaris extract.
After conducting behavioral tests, the antioxidant capacity and malondialdehyde (MDA) levels of
the rat’s serum and brain were measured.
Results: The results showed that the hydroalcoholic extract of B. vulgaris leaves increases the
antioxidant capacity of serum and brain. It also reduces the amount of MDA in serum and brain.
B. vulgaris extract enhances learning and improves motor balance.
Conclusion: This study showed that the hydroalcoholic extract of beet leaves firmly protects
brain damage caused by cerebral ischemia. The antioxidant property of this extract may explain
this effect. |
| format | Article |
| id | doaj-art-43c88ae229484f9abe81c7f9a8477bdc |
| institution | Kabale University |
| issn | 2783-4662 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Future Natural Products |
| spelling | doaj-art-43c88ae229484f9abe81c7f9a8477bdc2025-01-13T06:47:49ZengShahrekord University of Medical SciencesFuture Natural Products2783-46622024-12-0110171410.34172/fnp.165The effect of beet leaf (Beta vulgaris) extract on learning and memory after cerebral ischemic reperfusion in ratsKobra Mirahmadi0https://orcid.org/0009-0002-2481-8651Najmeh Asgharzadeh1https://orcid.org/0000-0002-4770-7033Zahra Lorigooini2https://orcid.org/0000-0003-0844-7571Marzieh Mardani3https://orcid.org/0000-0002-5353-1011Zahra Rabiei4https://orcid.org/0000-0003-0129-3581Diana Shahrani5https://orcid.org/0009-0006-1041-2086Mohamad Shahrani6https://orcid.org/0009-0005-9289-1959Mehrdad Shahrani Korrani7https://orcid.org/0000-0003-1284-3569Department of Education, Chaharmahal and Bakhtiari Province, Shahrekord, IranDepartment of Biology, Falavarjan Branch, Islamic Azad University, Medicinal Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranMedicinal Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedicinal Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedicinal Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranStudent Research Committee, Shahrekord University of Medical Sciences, Shahrekord, IranStudent Research Committee, Isfahan University of Medical Sciences, Isfahan, IranMedicinal Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranBackground and aims: Cerebral ischemia causes tissue oxidative damage and leads to cell death. Antioxidants can reduce the adverse effects of ischemia in the brain. This study was conducted to determine the effect of Beta vulgaris hydroalcoholic extract on learning and memory caused by transient cerebral ischemia. Methods: After preparing the herbal extract, the rats were divided into six groups: control, sham, ischemia, and 3 ischemic groups that received the extract. Ischemia was induced by bilateral carotid artery occlusion for 30 minutes. The control, sham, and ischemia groups received normal saline for two weeks. Three treatment groups received 50, 100, and 200 mg/kg B. vulgaris extract. After conducting behavioral tests, the antioxidant capacity and malondialdehyde (MDA) levels of the rat’s serum and brain were measured. Results: The results showed that the hydroalcoholic extract of B. vulgaris leaves increases the antioxidant capacity of serum and brain. It also reduces the amount of MDA in serum and brain. B. vulgaris extract enhances learning and improves motor balance. Conclusion: This study showed that the hydroalcoholic extract of beet leaves firmly protects brain damage caused by cerebral ischemia. The antioxidant property of this extract may explain this effect.http://fnp.skums.ac.ir/Article/fnp-165beta vulgarisbeet leavesmdaantioxidantrat |
| spellingShingle | Kobra Mirahmadi Najmeh Asgharzadeh Zahra Lorigooini Marzieh Mardani Zahra Rabiei Diana Shahrani Mohamad Shahrani Mehrdad Shahrani Korrani The effect of beet leaf (Beta vulgaris) extract on learning and memory after cerebral ischemic reperfusion in rats Future Natural Products beta vulgaris beet leaves mda antioxidant rat |
| title | The effect of beet leaf (Beta vulgaris) extract on learning and memory after cerebral ischemic reperfusion in rats |
| title_full | The effect of beet leaf (Beta vulgaris) extract on learning and memory after cerebral ischemic reperfusion in rats |
| title_fullStr | The effect of beet leaf (Beta vulgaris) extract on learning and memory after cerebral ischemic reperfusion in rats |
| title_full_unstemmed | The effect of beet leaf (Beta vulgaris) extract on learning and memory after cerebral ischemic reperfusion in rats |
| title_short | The effect of beet leaf (Beta vulgaris) extract on learning and memory after cerebral ischemic reperfusion in rats |
| title_sort | effect of beet leaf beta vulgaris extract on learning and memory after cerebral ischemic reperfusion in rats |
| topic | beta vulgaris beet leaves mda antioxidant rat |
| url | http://fnp.skums.ac.ir/Article/fnp-165 |
| work_keys_str_mv | AT kobramirahmadi theeffectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT najmehasgharzadeh theeffectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT zahralorigooini theeffectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT marziehmardani theeffectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT zahrarabiei theeffectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT dianashahrani theeffectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT mohamadshahrani theeffectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT mehrdadshahranikorrani theeffectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT kobramirahmadi effectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT najmehasgharzadeh effectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT zahralorigooini effectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT marziehmardani effectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT zahrarabiei effectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT dianashahrani effectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT mohamadshahrani effectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats AT mehrdadshahranikorrani effectofbeetleafbetavulgarisextractonlearningandmemoryaftercerebralischemicreperfusioninrats |