Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy
Objectives. Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine. The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failure in cancer patients who received plati...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/4918325 |
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| author | Ernesta Cavalcanti Vittoria Barchiesi Dionigio Cerasuolo Flaviano Di Paola Monica Cantile Sabrina Chiara Cecere Sandro Pignata Alessandro Morabito Raffaele Costanzo Massimo Di Maio Francesco Perrone |
| author_facet | Ernesta Cavalcanti Vittoria Barchiesi Dionigio Cerasuolo Flaviano Di Paola Monica Cantile Sabrina Chiara Cecere Sandro Pignata Alessandro Morabito Raffaele Costanzo Massimo Di Maio Francesco Perrone |
| author_sort | Ernesta Cavalcanti |
| collection | DOAJ |
| description | Objectives. Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine. The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failure in cancer patients who received platinum based chemotherapy. Design and Methods. Serum creatinine, serum cystatin C concentrations, and GFR were determined simultaneously in 52 cancer patients received carboplatin-based or cisplatin-based chemotherapy. Serum creatinine was assayed on Cobas C6000-Roche, serum cystatin C assay was performed on AIA 360-Tosoh, and GFR was determined in all patients, before the first cycle of chemotherapy and before the subsequent administrations. Results. In the overall series, for the prediction of a fall of GFR < 80 mL/min/1.73 m2, the AUC of the ROC curve for cystatin C was 0,667 and the best threshold was 1.135 mg/L (sensitivity 90.5%, specificity 61.1%). For a GFR fall < 60 mL/min/1.73 m2, the AUC of ROC curve for cystatin C was 74.3% and the best threshold was 1.415 mg/L (sensitivity 66.7%, specificity 73.2%). Conclusions. Baseline cystatin C values were not able to predict renal failure during subsequent treatment. In conclusion, serum cystatin C is not a reliable early marker to efficiently predict renal failure in patients receiving chemotherapy. |
| format | Article |
| id | doaj-art-43c32e2b4338434e843759fb1c609249 |
| institution | OA Journals |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-43c32e2b4338434e843759fb1c6092492025-08-20T02:05:52ZengWileyAnalytical Cellular Pathology2210-71772210-71852016-01-01201610.1155/2016/49183254918325Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based ChemotherapyErnesta Cavalcanti0Vittoria Barchiesi1Dionigio Cerasuolo2Flaviano Di Paola3Monica Cantile4Sabrina Chiara Cecere5Sandro Pignata6Alessandro Morabito7Raffaele Costanzo8Massimo Di Maio9Francesco Perrone10Laboratory Medicine Unit, Department of Diagnostic Pathology and Laboratory, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, ItalyLaboratory Medicine Unit, Department of Diagnostic Pathology and Laboratory, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, ItalyLaboratory Medicine Unit, Department of Diagnostic Pathology and Laboratory, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, ItalyLaboratory Medicine Unit, Department of Diagnostic Pathology and Laboratory, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, ItalyLaboratory Medicine Unit, Department of Diagnostic Pathology and Laboratory, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, ItalyUroginecologic Department, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, ItalyUroginecologic Department, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, ItalyThoraco-Pulmonary Medical Oncology Unit, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, ItalyThoraco-Pulmonary Medical Oncology Unit, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, ItalyClinical Trials Unit, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, ItalyClinical Trials Unit, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, ItalyObjectives. Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine. The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failure in cancer patients who received platinum based chemotherapy. Design and Methods. Serum creatinine, serum cystatin C concentrations, and GFR were determined simultaneously in 52 cancer patients received carboplatin-based or cisplatin-based chemotherapy. Serum creatinine was assayed on Cobas C6000-Roche, serum cystatin C assay was performed on AIA 360-Tosoh, and GFR was determined in all patients, before the first cycle of chemotherapy and before the subsequent administrations. Results. In the overall series, for the prediction of a fall of GFR < 80 mL/min/1.73 m2, the AUC of the ROC curve for cystatin C was 0,667 and the best threshold was 1.135 mg/L (sensitivity 90.5%, specificity 61.1%). For a GFR fall < 60 mL/min/1.73 m2, the AUC of ROC curve for cystatin C was 74.3% and the best threshold was 1.415 mg/L (sensitivity 66.7%, specificity 73.2%). Conclusions. Baseline cystatin C values were not able to predict renal failure during subsequent treatment. In conclusion, serum cystatin C is not a reliable early marker to efficiently predict renal failure in patients receiving chemotherapy.http://dx.doi.org/10.1155/2016/4918325 |
| spellingShingle | Ernesta Cavalcanti Vittoria Barchiesi Dionigio Cerasuolo Flaviano Di Paola Monica Cantile Sabrina Chiara Cecere Sandro Pignata Alessandro Morabito Raffaele Costanzo Massimo Di Maio Francesco Perrone Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy Analytical Cellular Pathology |
| title | Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy |
| title_full | Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy |
| title_fullStr | Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy |
| title_full_unstemmed | Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy |
| title_short | Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy |
| title_sort | correlation of serum cystatin c with glomerular filtration rate in patients receiving platinum based chemotherapy |
| url | http://dx.doi.org/10.1155/2016/4918325 |
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