Effect of SARS-CoV-2 infection on liver function in patients with hepatitis B
Abstract Objective To investigate the impact of SARS-CoV-2 infection on liver function and prognosis in patients with HBV infection. Methods A total of 154 HBV-positive patients (HBV ( +) group) and 154 HBV-negative patients (HBV (-) group) diagnosed with COVID-19 at Taizhou Hospital between Decembe...
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BMC
2024-12-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-024-10324-0 |
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| author | Tong Sun Hongbo Chi Jing Wang Yufen Zheng Hongguo Zhu Jingxian Zhao Kai Zhou Mengyuan Chen Donglian Wang Tao-Hsin Tung Jiaqin Xu Bo Shen |
| author_facet | Tong Sun Hongbo Chi Jing Wang Yufen Zheng Hongguo Zhu Jingxian Zhao Kai Zhou Mengyuan Chen Donglian Wang Tao-Hsin Tung Jiaqin Xu Bo Shen |
| author_sort | Tong Sun |
| collection | DOAJ |
| description | Abstract Objective To investigate the impact of SARS-CoV-2 infection on liver function and prognosis in patients with HBV infection. Methods A total of 154 HBV-positive patients (HBV ( +) group) and 154 HBV-negative patients (HBV (-) group) diagnosed with COVID-19 at Taizhou Hospital between December 10, 2022, and January 31, 2023, were included in this study. Clinical characteristics, treatment, and laboratory findings were collected from patients at three time points: before (T1), during (T2), and at the time of discharge (T3) from SARS-CoV-2 infection. Results Compared to the HBV (-) group, the HBV ( +) group had a longer hospital stay (15 (9–22) days vs. 9 (5–16) days). Longitudinal comparisons of laboratory indicators from T1 to T3 showed a continuous decline in TP and ALB levels and a continuous increase in PT and TT levels in the HBV ( +) group. BUN levels increased during T2 and decreased thereafter. These differences were considered statistically significant (P < 0.05). Notably, the HBV ( +) group had a higher proportion of indicators elevated > 3 ULN from T1 to T2, including ALT (1.95%/5.19%), AST (3.25%/12.99%), ALP (1.95%/3.25%), GGT (4.55%/9.09%), TBIL (6.49%/9.09%), and DBIL (18.18%/22.73%). In the HBV (-) group, the elevations were mainly concentrated within 1–2 ULN, including AST (12.99%/22.08%), DBIL (10.39%/21.43%), BUN (12.99%/22.08%), CREA (20.13%/29.22%), and PLT (7.79%/14.94%). Furthermore, the incidence of liver injury from T1 to T3 was higher in the HBV ( +) group compared to the HBV (-) group (15.7% (20/127) vs. 7.2% (11/152), P < 0.05). Multivariate analysis showed that liver cirrhosis (HR = 4.847, 95% CI: 1.224–19.20, P = 0.025) and liver cancer (HR = 8.333, 95% CI: 2.156–32.209, P = 0.002) were independent risk factors for liver injury in the presence of SARS-CoV-2 infection. Conclusion SARS-CoV-2 infection has a higher proportion of liver injury in HBV-infected patients, affecting hepatic protein synthesis function. Those with cirrhosis and hepatocellular carcinoma are at higher risk of severe liver injury. |
| format | Article |
| id | doaj-art-43be8e3b77d147ecab9a042983defa8a |
| institution | OA Journals |
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| publishDate | 2024-12-01 |
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| series | BMC Infectious Diseases |
| spelling | doaj-art-43be8e3b77d147ecab9a042983defa8a2025-08-20T02:31:44ZengBMCBMC Infectious Diseases1471-23342024-12-0124111410.1186/s12879-024-10324-0Effect of SARS-CoV-2 infection on liver function in patients with hepatitis BTong Sun0Hongbo Chi1Jing Wang2Yufen Zheng3Hongguo Zhu4Jingxian Zhao5Kai Zhou6Mengyuan Chen7Donglian Wang8Tao-Hsin Tung9Jiaqin Xu10Bo Shen11Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou, Medical UniversityDepartment of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou, Medical UniversityDepartment of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou, Medical UniversityDepartment of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou, Medical UniversityDepartment of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou, Medical UniversityDepartment of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou, Medical UniversityDepartment of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou, Medical UniversityDepartment of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou, Medical UniversityDepartment of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou, Medical UniversityEvidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to WenzhouMedical UniversityDepartment of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou, Medical UniversityDepartment of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou, Medical UniversityAbstract Objective To investigate the impact of SARS-CoV-2 infection on liver function and prognosis in patients with HBV infection. Methods A total of 154 HBV-positive patients (HBV ( +) group) and 154 HBV-negative patients (HBV (-) group) diagnosed with COVID-19 at Taizhou Hospital between December 10, 2022, and January 31, 2023, were included in this study. Clinical characteristics, treatment, and laboratory findings were collected from patients at three time points: before (T1), during (T2), and at the time of discharge (T3) from SARS-CoV-2 infection. Results Compared to the HBV (-) group, the HBV ( +) group had a longer hospital stay (15 (9–22) days vs. 9 (5–16) days). Longitudinal comparisons of laboratory indicators from T1 to T3 showed a continuous decline in TP and ALB levels and a continuous increase in PT and TT levels in the HBV ( +) group. BUN levels increased during T2 and decreased thereafter. These differences were considered statistically significant (P < 0.05). Notably, the HBV ( +) group had a higher proportion of indicators elevated > 3 ULN from T1 to T2, including ALT (1.95%/5.19%), AST (3.25%/12.99%), ALP (1.95%/3.25%), GGT (4.55%/9.09%), TBIL (6.49%/9.09%), and DBIL (18.18%/22.73%). In the HBV (-) group, the elevations were mainly concentrated within 1–2 ULN, including AST (12.99%/22.08%), DBIL (10.39%/21.43%), BUN (12.99%/22.08%), CREA (20.13%/29.22%), and PLT (7.79%/14.94%). Furthermore, the incidence of liver injury from T1 to T3 was higher in the HBV ( +) group compared to the HBV (-) group (15.7% (20/127) vs. 7.2% (11/152), P < 0.05). Multivariate analysis showed that liver cirrhosis (HR = 4.847, 95% CI: 1.224–19.20, P = 0.025) and liver cancer (HR = 8.333, 95% CI: 2.156–32.209, P = 0.002) were independent risk factors for liver injury in the presence of SARS-CoV-2 infection. Conclusion SARS-CoV-2 infection has a higher proportion of liver injury in HBV-infected patients, affecting hepatic protein synthesis function. Those with cirrhosis and hepatocellular carcinoma are at higher risk of severe liver injury.https://doi.org/10.1186/s12879-024-10324-0SARS-CoV-2Liver functionHBVLiver injury |
| spellingShingle | Tong Sun Hongbo Chi Jing Wang Yufen Zheng Hongguo Zhu Jingxian Zhao Kai Zhou Mengyuan Chen Donglian Wang Tao-Hsin Tung Jiaqin Xu Bo Shen Effect of SARS-CoV-2 infection on liver function in patients with hepatitis B BMC Infectious Diseases SARS-CoV-2 Liver function HBV Liver injury |
| title | Effect of SARS-CoV-2 infection on liver function in patients with hepatitis B |
| title_full | Effect of SARS-CoV-2 infection on liver function in patients with hepatitis B |
| title_fullStr | Effect of SARS-CoV-2 infection on liver function in patients with hepatitis B |
| title_full_unstemmed | Effect of SARS-CoV-2 infection on liver function in patients with hepatitis B |
| title_short | Effect of SARS-CoV-2 infection on liver function in patients with hepatitis B |
| title_sort | effect of sars cov 2 infection on liver function in patients with hepatitis b |
| topic | SARS-CoV-2 Liver function HBV Liver injury |
| url | https://doi.org/10.1186/s12879-024-10324-0 |
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