Multimodal evaluation of cerebrospinal fluid from breast cancer leptomeningeal metastases using circulating tumor cell detection, single-cell sequencing, and proteomics

Multimodal evaluation of cerebrospinal fluid from breast cancer leptomeningeal metastases using circulating tumor cell detection, single-cell sequencing, and proteomics

Abstract Background Patients with human epidermal growth factor receptor 2 positive (HER2+) or triple-negative breast cancer are at higher risk than those with other breast cancer subtypes for developing brain metastases, including leptomeningeal metastases. Despite advances in the treatment of prim...

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Bibliographic Details
Main Authors: Elnaz Rahbarlayegh, Alexandre Wojcinski, Natsuko Nomura, Tiffany M. Juarez, Barbara Blouw, Santosh Kesari
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Cerebrospinal fluid
Leptomeningeal disease
Breast cancer
Sacituzumab govitecan
Single-cell sequencing
Circulating tumor cells
Online Access:https://doi.org/10.1186/s12967-025-06671-4
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