Anemia, Blood Transfusion, and Filter Life Span in Critically Ill Patients Requiring Continuous Renal Replacement Therapy for Acute Kidney Injury: A Case-Control Study
Background. Filter clotting is frequent during continuous renal replacement therapy (CRRT), which increases anemia risk. We studied anemia and blood transfusion in critically ill patients requiring CRRT for acute kidney injury and assessed the relationship between CRRT filter life span and PRBC tran...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/3737083 |
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| author | Hasan M. Al-Dorzi Nora Ali Alhumaid Nouf Hamad Alwelyee Nouf Mubark Albakheet Ramah Ibrahim Nazer Sadal Khalid Aldakhil Shahad Abdulaziz AlSaif Nazish Masud |
| author_facet | Hasan M. Al-Dorzi Nora Ali Alhumaid Nouf Hamad Alwelyee Nouf Mubark Albakheet Ramah Ibrahim Nazer Sadal Khalid Aldakhil Shahad Abdulaziz AlSaif Nazish Masud |
| author_sort | Hasan M. Al-Dorzi |
| collection | DOAJ |
| description | Background. Filter clotting is frequent during continuous renal replacement therapy (CRRT), which increases anemia risk. We studied anemia and blood transfusion in critically ill patients requiring CRRT for acute kidney injury and assessed the relationship between CRRT filter life span and PRBC transfusion. Methods. A case-control study was conducted at a tertiary-care intensive care unit (ICU) where CRRT cases were matched with controls for age, gender, admission category, and severity of illness. Daily hemoglobin levels, blood transfusions, and life span of CRRT filter were noted. CCRT patients were categorized according to the median of the filter life span (20 hours). Results. Ninety-five cases and 102 controls were enrolled. The hemoglobin level on admission was similar in the two groups, yet cases had significantly lower hemoglobin levels than controls (72.8 ± 15.3 versus 82.5 ± 20.7 g/L, p<0.001) during ICU stay. Anemia <70 g/L occurred in 50% of cases and 19% of controls (p<0.001). Most (56.3%) cases were transfused compared with 29.9% for controls (p<0.001) with higher number of transfused packed red blood cell (PRBC) units in cases (2.6 ± 4.0 versus 1.5 ± 3.2 units per patient, p=0.03). Patients with shorter versus longer filter life had similar hemoglobin level in the first 7 days of CRRT with no difference in PRBC transfusion requirement. Prefilter heparin use and hemodialysis access location were not associated with longer filter life span. The mortality was similar in patients with shorter versus longer filter life. Conclusions. CRRT in ICU was associated with larger drop in hemoglobin and more PRBC transfusion. Shorter (<20 hours) versus longer CCRT filter life was not associated with increased PRBC transfusion. |
| format | Article |
| id | doaj-art-43b3e87e193e4b5ca231f9c988f1da0a |
| institution | OA Journals |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-43b3e87e193e4b5ca231f9c988f1da0a2025-08-20T02:05:49ZengWileyCritical Care Research and Practice2090-13052090-13132019-01-01201910.1155/2019/37370833737083Anemia, Blood Transfusion, and Filter Life Span in Critically Ill Patients Requiring Continuous Renal Replacement Therapy for Acute Kidney Injury: A Case-Control StudyHasan M. Al-Dorzi0Nora Ali Alhumaid1Nouf Hamad Alwelyee2Nouf Mubark Albakheet3Ramah Ibrahim Nazer4Sadal Khalid Aldakhil5Shahad Abdulaziz AlSaif6Nazish Masud7Intensive Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi ArabiaKing Abdullah International Medical Research Center, Riyadh, Saudi ArabiaKing Abdullah International Medical Research Center, Riyadh, Saudi ArabiaKing Abdullah International Medical Research Center, Riyadh, Saudi ArabiaKing Abdullah International Medical Research Center, Riyadh, Saudi ArabiaKing Abdullah International Medical Research Center, Riyadh, Saudi ArabiaKing Abdullah International Medical Research Center, Riyadh, Saudi ArabiaKing Abdullah International Medical Research Center, Riyadh, Saudi ArabiaBackground. Filter clotting is frequent during continuous renal replacement therapy (CRRT), which increases anemia risk. We studied anemia and blood transfusion in critically ill patients requiring CRRT for acute kidney injury and assessed the relationship between CRRT filter life span and PRBC transfusion. Methods. A case-control study was conducted at a tertiary-care intensive care unit (ICU) where CRRT cases were matched with controls for age, gender, admission category, and severity of illness. Daily hemoglobin levels, blood transfusions, and life span of CRRT filter were noted. CCRT patients were categorized according to the median of the filter life span (20 hours). Results. Ninety-five cases and 102 controls were enrolled. The hemoglobin level on admission was similar in the two groups, yet cases had significantly lower hemoglobin levels than controls (72.8 ± 15.3 versus 82.5 ± 20.7 g/L, p<0.001) during ICU stay. Anemia <70 g/L occurred in 50% of cases and 19% of controls (p<0.001). Most (56.3%) cases were transfused compared with 29.9% for controls (p<0.001) with higher number of transfused packed red blood cell (PRBC) units in cases (2.6 ± 4.0 versus 1.5 ± 3.2 units per patient, p=0.03). Patients with shorter versus longer filter life had similar hemoglobin level in the first 7 days of CRRT with no difference in PRBC transfusion requirement. Prefilter heparin use and hemodialysis access location were not associated with longer filter life span. The mortality was similar in patients with shorter versus longer filter life. Conclusions. CRRT in ICU was associated with larger drop in hemoglobin and more PRBC transfusion. Shorter (<20 hours) versus longer CCRT filter life was not associated with increased PRBC transfusion.http://dx.doi.org/10.1155/2019/3737083 |
| spellingShingle | Hasan M. Al-Dorzi Nora Ali Alhumaid Nouf Hamad Alwelyee Nouf Mubark Albakheet Ramah Ibrahim Nazer Sadal Khalid Aldakhil Shahad Abdulaziz AlSaif Nazish Masud Anemia, Blood Transfusion, and Filter Life Span in Critically Ill Patients Requiring Continuous Renal Replacement Therapy for Acute Kidney Injury: A Case-Control Study Critical Care Research and Practice |
| title | Anemia, Blood Transfusion, and Filter Life Span in Critically Ill Patients Requiring Continuous Renal Replacement Therapy for Acute Kidney Injury: A Case-Control Study |
| title_full | Anemia, Blood Transfusion, and Filter Life Span in Critically Ill Patients Requiring Continuous Renal Replacement Therapy for Acute Kidney Injury: A Case-Control Study |
| title_fullStr | Anemia, Blood Transfusion, and Filter Life Span in Critically Ill Patients Requiring Continuous Renal Replacement Therapy for Acute Kidney Injury: A Case-Control Study |
| title_full_unstemmed | Anemia, Blood Transfusion, and Filter Life Span in Critically Ill Patients Requiring Continuous Renal Replacement Therapy for Acute Kidney Injury: A Case-Control Study |
| title_short | Anemia, Blood Transfusion, and Filter Life Span in Critically Ill Patients Requiring Continuous Renal Replacement Therapy for Acute Kidney Injury: A Case-Control Study |
| title_sort | anemia blood transfusion and filter life span in critically ill patients requiring continuous renal replacement therapy for acute kidney injury a case control study |
| url | http://dx.doi.org/10.1155/2019/3737083 |
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