Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives
Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N′-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide derivatives were obtained via reaction of 2-[4-(4-nitrophenyl)piperazin...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/5878410 |
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| author | Betül Kaya Yusuf Özkay Halide Edip Temel Zafer Asım Kaplancıklı |
| author_facet | Betül Kaya Yusuf Özkay Halide Edip Temel Zafer Asım Kaplancıklı |
| author_sort | Betül Kaya |
| collection | DOAJ |
| description | Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N′-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide derivatives were obtained via reaction of 2-[4-(4-nitrophenyl)piperazin-1-yl]acetohydrazide with aromatic aldehydes. The chemical structures of the compounds were enlightened by FT-IR, 1H-NMR, 13C-NMR, and HRMS (ESI) spectral data. The inhibition potency of the compounds 3a–k against AChE and BuChE was measured and evaluated using a modification of Ellman’s spectrophotometric method. Among the tested compounds, compound 3c was assigned to be the most active derivative. Galantamine was used as a standard drug. |
| format | Article |
| id | doaj-art-43b2ece9ef8d420cbc7fe8209ffcbe14 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-43b2ece9ef8d420cbc7fe8209ffcbe142025-02-03T05:51:03ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/58784105878410Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone DerivativesBetül Kaya0Yusuf Özkay1Halide Edip Temel2Zafer Asım Kaplancıklı3Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, 26470 Eskişehir, TurkeyFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, 26470 Eskişehir, TurkeyFaculty of Pharmacy, Department of Biochemistry, Anadolu University, 26470 Eskişehir, TurkeyFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, 26470 Eskişehir, TurkeySome hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N′-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide derivatives were obtained via reaction of 2-[4-(4-nitrophenyl)piperazin-1-yl]acetohydrazide with aromatic aldehydes. The chemical structures of the compounds were enlightened by FT-IR, 1H-NMR, 13C-NMR, and HRMS (ESI) spectral data. The inhibition potency of the compounds 3a–k against AChE and BuChE was measured and evaluated using a modification of Ellman’s spectrophotometric method. Among the tested compounds, compound 3c was assigned to be the most active derivative. Galantamine was used as a standard drug.http://dx.doi.org/10.1155/2016/5878410 |
| spellingShingle | Betül Kaya Yusuf Özkay Halide Edip Temel Zafer Asım Kaplancıklı Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives Journal of Chemistry |
| title | Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives |
| title_full | Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives |
| title_fullStr | Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives |
| title_full_unstemmed | Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives |
| title_short | Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives |
| title_sort | synthesis and biological evaluation of novel piperazine containing hydrazone derivatives |
| url | http://dx.doi.org/10.1155/2016/5878410 |
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