Prokaryotic and Eukaryotic DNA in Prevention and Treatment of Infectious Diseases
The review article presents the materials of recent years dedicated to the analysis of modern data about the possible aspects of the use of deoxyribonucleic acid (DNA) and oligodesoxinucleotides (natural and synthetic) from pro - and eukaryotes for the prevention and treatment of infectious diseases...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/86 |
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| author | N. N. Besednova I. D. Makarenkova L. N. Fedyanina ZH. I. Avdeeva S. P. Kryzshanovsky T. A. Kuznetsova T. S. Zaporozhets |
| author_facet | N. N. Besednova I. D. Makarenkova L. N. Fedyanina ZH. I. Avdeeva S. P. Kryzshanovsky T. A. Kuznetsova T. S. Zaporozhets |
| author_sort | N. N. Besednova |
| collection | DOAJ |
| description | The review article presents the materials of recent years dedicated to the analysis of modern data about the possible aspects of the use of deoxyribonucleic acid (DNA) and oligodesoxinucleotides (natural and synthetic) from pro - and eukaryotes for the prevention and treatment of infectious diseases.The authors focus on bacterial DNA with a high content of CpG motifs, as well as on unmethylated CpG oligonucleotides (CpG-ODN), which stimulate the system of innate and adaptive immunity. Due to the absence of pronounced toxicity and good tolerance of the macroorganism, these compounds are of great interest for medical use, in particular as adjuvants. At the same time, the authors note the need to develop effective CpG-ODN delivery systems in tissues and target cells.With respect to CpG-motives of eukaryotic DNA, the possibility of their use as a basis for effective adjuvants, immunomodulators, antiviral and antibacterial compounds is considered. |
| format | Article |
| id | doaj-art-43b0a08094ef4f038db288683a97fe25 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-43b0a08094ef4f038db288683a97fe252025-08-20T03:42:02ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01635-6526785Prokaryotic and Eukaryotic DNA in Prevention and Treatment of Infectious DiseasesN. N. Besednova0I. D. Makarenkova1L. N. Fedyanina2ZH. I. Avdeeva3S. P. Kryzshanovsky4T. A. Kuznetsova5T. S. Zaporozhets6G.P. Somov Research Institute of Epidemiology and MicrobiologyG.P. Somov Research Institute of Epidemiology and MicrobiologyFar Eastern Federal University, School of BiomedicineScientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian FederationVladivostok State Medical University of the Ministry of Health of the Russian FederationG.P. Somov Research Institute of Epidemiology and Microbiology; Far Eastern Federal University, School of BiomedicineG.P. Somov Research Institute of Epidemiology and MicrobiologyThe review article presents the materials of recent years dedicated to the analysis of modern data about the possible aspects of the use of deoxyribonucleic acid (DNA) and oligodesoxinucleotides (natural and synthetic) from pro - and eukaryotes for the prevention and treatment of infectious diseases.The authors focus on bacterial DNA with a high content of CpG motifs, as well as on unmethylated CpG oligonucleotides (CpG-ODN), which stimulate the system of innate and adaptive immunity. Due to the absence of pronounced toxicity and good tolerance of the macroorganism, these compounds are of great interest for medical use, in particular as adjuvants. At the same time, the authors note the need to develop effective CpG-ODN delivery systems in tissues and target cells.With respect to CpG-motives of eukaryotic DNA, the possibility of their use as a basis for effective adjuvants, immunomodulators, antiviral and antibacterial compounds is considered.https://www.antibiotics-chemotherapy.ru/jour/article/view/86cpg-олигодезоксинуклеотиды (cpg-odn)deoxyribonucleic acid (dna)cpg-oligonucleotide (cpg-odn)adjuvantsinfectious diseaseinnate and adaptive immunity |
| spellingShingle | N. N. Besednova I. D. Makarenkova L. N. Fedyanina ZH. I. Avdeeva S. P. Kryzshanovsky T. A. Kuznetsova T. S. Zaporozhets Prokaryotic and Eukaryotic DNA in Prevention and Treatment of Infectious Diseases Антибиотики и Химиотерапия cpg-олигодезоксинуклеотиды (cpg-odn) deoxyribonucleic acid (dna) cpg-oligonucleotide (cpg-odn) adjuvants infectious disease innate and adaptive immunity |
| title | Prokaryotic and Eukaryotic DNA in Prevention and Treatment of Infectious Diseases |
| title_full | Prokaryotic and Eukaryotic DNA in Prevention and Treatment of Infectious Diseases |
| title_fullStr | Prokaryotic and Eukaryotic DNA in Prevention and Treatment of Infectious Diseases |
| title_full_unstemmed | Prokaryotic and Eukaryotic DNA in Prevention and Treatment of Infectious Diseases |
| title_short | Prokaryotic and Eukaryotic DNA in Prevention and Treatment of Infectious Diseases |
| title_sort | prokaryotic and eukaryotic dna in prevention and treatment of infectious diseases |
| topic | cpg-олигодезоксинуклеотиды (cpg-odn) deoxyribonucleic acid (dna) cpg-oligonucleotide (cpg-odn) adjuvants infectious disease innate and adaptive immunity |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/86 |
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