Wound-healing and polymorphisms in platelet 5-HTR2A receptors: a molecular approach
Wound healing involves a well-orchestrated sequence of complex and dynamic events that occur in different phases: hemostasis, inflammation, proliferation, contraction, and remodeling. Each phase is characterized by specific cellular and molecular events that contribute to the repair of da...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academia.edu Journals
2024-08-01
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| Series: | Academia Molecular Biology and Genomics |
| Online Access: | https://www.academia.edu/122867965/Wound_healing_and_polymorphisms_in_platelet_5_HTR2A_receptors_a_molecular_approach |
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| Summary: | Wound healing involves a well-orchestrated sequence of complex and dynamic events that occur in different phases: hemostasis, inflammation, proliferation, contraction, and remodeling. Each phase is characterized by specific cellular and molecular events that contribute to the repair of damaged tissues and can be influenced by several factors, including genetics. The serotonin receptor gene 5-hydroxytryptamine receptor-2A (5-HTR2A), encodes 5-HTR2A receptors which are a type of serotonin receptor. These receptors, which secrete serotonin during platelet activation, play an important role in wound healing, particularly in the phases of hemostasis, inflammation, proliferation, and angiogenesis, facilitating efficient and adequate tissue repair. Genetic changes or polymorphisms, especially the 102T-C polymorphism, can significantly impact these tissue-healing processes in the 5-HTR2A gene, by influencing the expression of platelet 5-HTR2A receptors. This review highlights the need for a new look to broaden the horizons of molecular understanding of tissue repair and wound healing. |
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| ISSN: | 3064-9765 |