The effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy: Protocol for a systematic review and meta-analysis
Non-invasive brain stimulation (NIBS11 Non-invasive brain stimulation.) techniques have emerged as a promising non-pharmacological adjunct to neurorehabilitation. Children with Cerebral Palsy (CP22 Cerebral Palsy.) exhibit altered cortical excitability, and while CP remains incurable, physiotherapy...
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Elsevier
2025-06-01
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| author | Clàudia Arumí-Trujillo Francisco José Verdejo-Amengual Oriol Martínez-Navarro Jord J.T. Vink Fran Valenzuela-Pascual |
| author_facet | Clàudia Arumí-Trujillo Francisco José Verdejo-Amengual Oriol Martínez-Navarro Jord J.T. Vink Fran Valenzuela-Pascual |
| author_sort | Clàudia Arumí-Trujillo |
| collection | DOAJ |
| description | Non-invasive brain stimulation (NIBS11 Non-invasive brain stimulation.) techniques have emerged as a promising non-pharmacological adjunct to neurorehabilitation. Children with Cerebral Palsy (CP22 Cerebral Palsy.) exhibit altered cortical excitability, and while CP remains incurable, physiotherapy combined with other interventions is essential for managing motor dysfunction. Although some studies have examined NIBS using various stimulation parameters, there is limited evidence regarding its effects on the lower extremities and optimal administration protocols. This review aims to evaluate the effectiveness of NIBS techniques, such as transcranial direct current stimulation (tDCS33 Transcranial Direct Current Stimulation.) and repetitive transcranial magnetic stimulation (rTMS44 Repetitive Transcranial Magnetic Stimulation.), for the treatment of motor function in spastic cerebral palsy, specifically in the lower extremity. A systematic search will be conducted in databases including MEDLINE, CINAHL Plus, EMBASE, Scopus, ISI Web of Science, and the Cochrane Central Register of Controlled Trials. The search strategy will follow the PICO framework (Participants, Intervention, Comparison, Outcomes), focusing on randomized controlled trials (RCTs). Two independent reviewers will manage screening, selection, data extraction, risk of bias assessment, and grading of evidence. This review will provide key insights into the effectiveness of NIBS for lower-extremity function in children with spastic CP, guiding future research and clinical applications. |
| format | Article |
| id | doaj-art-43a49a27a432411ba06cd7403c6fa74e |
| institution | Kabale University |
| issn | 2215-0161 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | MethodsX |
| spelling | doaj-art-43a49a27a432411ba06cd7403c6fa74e2025-01-04T04:56:27ZengElsevierMethodsX2215-01612025-06-0114103141The effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy: Protocol for a systematic review and meta-analysisClàudia Arumí-Trujillo0Francisco José Verdejo-Amengual1Oriol Martínez-Navarro2Jord J.T. Vink3Fran Valenzuela-Pascual4Faculty of Nursing and Physiotherapy, Universidad de Lleida, Roig 2, 25198 Lleida, Montserrat, España; Translational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, the Netherlands; Corresponding author.Faculty of Nursing and Physiotherapy, Universidad de Lleida, Roig 2, 25198 Lleida, Montserrat, España; Research Group of Health Care (GReCS), Lleida Biomedical Research Institute's Dr. Pifarre Foundation (IRB Lleida), Avda Alcalde Rovira Roure 80, 25198 Lleida, EspañaFaculty of Nursing and Physiotherapy, Universidad de Lleida, Roig 2, 25198 Lleida, Montserrat, España; Group of Studies on Society, Health, Education and Culture (GESEC), Universidad de Lleida, Pl. de Víctor Siurana 1, 25003 Lleida, EspañaTranslational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, the Netherlands; Center of Excellence in Rehabilitation Medicine, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University and De Hoogstraat Rehabilitation, the NetherlandsFaculty of Nursing and Physiotherapy, Universidad de Lleida, Roig 2, 25198 Lleida, Montserrat, España; Group of Studies on Society, Health, Education and Culture (GESEC), Universidad de Lleida, Pl. de Víctor Siurana 1, 25003 Lleida, España; Research Group of Health Care (GReCS), Lleida Biomedical Research Institute's Dr. Pifarre Foundation (IRB Lleida), Avda Alcalde Rovira Roure 80, 25198 Lleida, EspañaNon-invasive brain stimulation (NIBS11 Non-invasive brain stimulation.) techniques have emerged as a promising non-pharmacological adjunct to neurorehabilitation. Children with Cerebral Palsy (CP22 Cerebral Palsy.) exhibit altered cortical excitability, and while CP remains incurable, physiotherapy combined with other interventions is essential for managing motor dysfunction. Although some studies have examined NIBS using various stimulation parameters, there is limited evidence regarding its effects on the lower extremities and optimal administration protocols. This review aims to evaluate the effectiveness of NIBS techniques, such as transcranial direct current stimulation (tDCS33 Transcranial Direct Current Stimulation.) and repetitive transcranial magnetic stimulation (rTMS44 Repetitive Transcranial Magnetic Stimulation.), for the treatment of motor function in spastic cerebral palsy, specifically in the lower extremity. A systematic search will be conducted in databases including MEDLINE, CINAHL Plus, EMBASE, Scopus, ISI Web of Science, and the Cochrane Central Register of Controlled Trials. The search strategy will follow the PICO framework (Participants, Intervention, Comparison, Outcomes), focusing on randomized controlled trials (RCTs). Two independent reviewers will manage screening, selection, data extraction, risk of bias assessment, and grading of evidence. This review will provide key insights into the effectiveness of NIBS for lower-extremity function in children with spastic CP, guiding future research and clinical applications.http://www.sciencedirect.com/science/article/pii/S2215016124005922A protocol for a systematic review and meta-analysis to evaluate the effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy |
| spellingShingle | Clàudia Arumí-Trujillo Francisco José Verdejo-Amengual Oriol Martínez-Navarro Jord J.T. Vink Fran Valenzuela-Pascual The effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy: Protocol for a systematic review and meta-analysis MethodsX A protocol for a systematic review and meta-analysis to evaluate the effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy |
| title | The effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy: Protocol for a systematic review and meta-analysis |
| title_full | The effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy: Protocol for a systematic review and meta-analysis |
| title_fullStr | The effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy: Protocol for a systematic review and meta-analysis |
| title_full_unstemmed | The effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy: Protocol for a systematic review and meta-analysis |
| title_short | The effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy: Protocol for a systematic review and meta-analysis |
| title_sort | effectiveness of non invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy protocol for a systematic review and meta analysis |
| topic | A protocol for a systematic review and meta-analysis to evaluate the effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy |
| url | http://www.sciencedirect.com/science/article/pii/S2215016124005922 |
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