Aromatic Amino Acids: Exploring Microalgae as a Potential Biofactory
In recent times, microalgae have emerged as powerful hosts for biotechnological applications, ranging from the production of lipids and specialized metabolites (SMs) of pharmaceutical interest to biofuels, nutraceutical supplements, and more. SM synthesis through bioengineered pathways relies on the...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | BioTech |
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| Online Access: | https://www.mdpi.com/2673-6284/14/1/6 |
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| author | Archana Niraula Amir Danesh Natacha Merindol Fatma Meddeb-Mouelhi Isabel Desgagné-Penix |
| author_facet | Archana Niraula Amir Danesh Natacha Merindol Fatma Meddeb-Mouelhi Isabel Desgagné-Penix |
| author_sort | Archana Niraula |
| collection | DOAJ |
| description | In recent times, microalgae have emerged as powerful hosts for biotechnological applications, ranging from the production of lipids and specialized metabolites (SMs) of pharmaceutical interest to biofuels, nutraceutical supplements, and more. SM synthesis through bioengineered pathways relies on the availability of aromatic amino acids (AAAs) as an essential precursor. AAAs, phenylalanine, tyrosine, and tryptophan are also the building blocks of proteins, maintaining the structural and functional integrity of cells. Hence, they are crucial intermediates linking the primary and specialized metabolism. The biosynthesis pathway of AAAs in microbes and plants has been studied for decades, but not much is known about microalgae. The allosteric control present in this pathway has been targeted for metabolic engineering in microbes. This review focuses on the biosynthesis of AAAs in eukaryotic microalgae and engineering techniques for enhanced production. All the putative genes involved in AAA pathways in the model microalgae <i>Chlamydomonas reinhardtii</i> and <i>Phaeodactylum tricornutum</i> are listed in this review. |
| format | Article |
| id | doaj-art-43a32b8024124975b967601d37dced71 |
| institution | DOAJ |
| issn | 2673-6284 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | BioTech |
| spelling | doaj-art-43a32b8024124975b967601d37dced712025-08-20T02:42:46ZengMDPI AGBioTech2673-62842025-01-01141610.3390/biotech14010006Aromatic Amino Acids: Exploring Microalgae as a Potential BiofactoryArchana Niraula0Amir Danesh1Natacha Merindol2Fatma Meddeb-Mouelhi3Isabel Desgagné-Penix4Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, CanadaDepartment of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, CanadaDepartment of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, CanadaDepartment of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, CanadaDepartment of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, CanadaIn recent times, microalgae have emerged as powerful hosts for biotechnological applications, ranging from the production of lipids and specialized metabolites (SMs) of pharmaceutical interest to biofuels, nutraceutical supplements, and more. SM synthesis through bioengineered pathways relies on the availability of aromatic amino acids (AAAs) as an essential precursor. AAAs, phenylalanine, tyrosine, and tryptophan are also the building blocks of proteins, maintaining the structural and functional integrity of cells. Hence, they are crucial intermediates linking the primary and specialized metabolism. The biosynthesis pathway of AAAs in microbes and plants has been studied for decades, but not much is known about microalgae. The allosteric control present in this pathway has been targeted for metabolic engineering in microbes. This review focuses on the biosynthesis of AAAs in eukaryotic microalgae and engineering techniques for enhanced production. All the putative genes involved in AAA pathways in the model microalgae <i>Chlamydomonas reinhardtii</i> and <i>Phaeodactylum tricornutum</i> are listed in this review.https://www.mdpi.com/2673-6284/14/1/6shikimate pathway<i>Chlamydomonas reinhardtii</i>chorismate mutase<i>Phaeodactylum tricornutum</i>metabolic engineering |
| spellingShingle | Archana Niraula Amir Danesh Natacha Merindol Fatma Meddeb-Mouelhi Isabel Desgagné-Penix Aromatic Amino Acids: Exploring Microalgae as a Potential Biofactory BioTech shikimate pathway <i>Chlamydomonas reinhardtii</i> chorismate mutase <i>Phaeodactylum tricornutum</i> metabolic engineering |
| title | Aromatic Amino Acids: Exploring Microalgae as a Potential Biofactory |
| title_full | Aromatic Amino Acids: Exploring Microalgae as a Potential Biofactory |
| title_fullStr | Aromatic Amino Acids: Exploring Microalgae as a Potential Biofactory |
| title_full_unstemmed | Aromatic Amino Acids: Exploring Microalgae as a Potential Biofactory |
| title_short | Aromatic Amino Acids: Exploring Microalgae as a Potential Biofactory |
| title_sort | aromatic amino acids exploring microalgae as a potential biofactory |
| topic | shikimate pathway <i>Chlamydomonas reinhardtii</i> chorismate mutase <i>Phaeodactylum tricornutum</i> metabolic engineering |
| url | https://www.mdpi.com/2673-6284/14/1/6 |
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