Research progress on female reproductive toxicity of bisphenols
Bisphenols (BPs) are extensively used in food packaging, personal care products, and plastics, making them prevalent in both living and working environments, which has raised significant concern. As endocrine-disrupting chemicals, BPs exert toxic effects on the female reproductive system by binding...
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| Format: | Article |
| Language: | English |
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Editorial Committee of Journal of Environmental and Occupational Medicine
2025-07-01
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| Series: | 环境与职业医学 |
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| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM24493 |
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| author | Jia PENG Xiangzhu YAN Jiasi LIU Xiaopeng ZHONG Simin YAO Yiyan MA Shuhua TAN |
| author_facet | Jia PENG Xiangzhu YAN Jiasi LIU Xiaopeng ZHONG Simin YAO Yiyan MA Shuhua TAN |
| author_sort | Jia PENG |
| collection | DOAJ |
| description | Bisphenols (BPs) are extensively used in food packaging, personal care products, and plastics, making them prevalent in both living and working environments, which has raised significant concern. As endocrine-disrupting chemicals, BPs exert toxic effects on the female reproductive system by binding to estrogen receptors, thereby activating or inhibiting the expression of genes related to reproductive functions, which disrupts the normal function of the endocrine system. This paper reviewed the effects of bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF) on female reproductive function, focusing on three key aspects: the effects on the female reproductive organs, the occurrence of associated reproductive disorders, and the mechanisms of toxicity. Specifically, this review highlighted the effects on ovarian function, uterine morphology and function, and fallopian tube function, as well as their correlation with polycystic ovary syndrome, endometriosis, miscarriage, and eclampsia. Additionally, the toxic mechanisms of BPs exposure were summarized, providing a scientific basis for future research on the impact of BPs on the female reproductive system, as well as for the assessment of potential health risks and the development of preventive measures. |
| format | Article |
| id | doaj-art-43a319c0d20f4ba0b2a4a84b3cc6d89f |
| institution | Kabale University |
| issn | 2095-9982 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj-art-43a319c0d20f4ba0b2a4a84b3cc6d89f2025-08-20T03:41:40ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822025-07-0142786286910.11836/JEOM2449324493Research progress on female reproductive toxicity of bisphenolsJia PENG0Xiangzhu YAN1Jiasi LIU2Xiaopeng ZHONG3Simin YAO4Yiyan MA5Shuhua TAN6School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan, Hunan 411201, ChinaSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan, Hunan 411201, ChinaSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan, Hunan 411201, ChinaSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan, Hunan 411201, ChinaSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan, Hunan 411201, ChinaSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan, Hunan 411201, ChinaSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan, Hunan 411201, ChinaBisphenols (BPs) are extensively used in food packaging, personal care products, and plastics, making them prevalent in both living and working environments, which has raised significant concern. As endocrine-disrupting chemicals, BPs exert toxic effects on the female reproductive system by binding to estrogen receptors, thereby activating or inhibiting the expression of genes related to reproductive functions, which disrupts the normal function of the endocrine system. This paper reviewed the effects of bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF) on female reproductive function, focusing on three key aspects: the effects on the female reproductive organs, the occurrence of associated reproductive disorders, and the mechanisms of toxicity. Specifically, this review highlighted the effects on ovarian function, uterine morphology and function, and fallopian tube function, as well as their correlation with polycystic ovary syndrome, endometriosis, miscarriage, and eclampsia. Additionally, the toxic mechanisms of BPs exposure were summarized, providing a scientific basis for future research on the impact of BPs on the female reproductive system, as well as for the assessment of potential health risks and the development of preventive measures.http://www.jeom.org/article/cn/10.11836/JEOM24493bisphenolsfemale reproductive systemendocrine disruptionreproductive toxicity |
| spellingShingle | Jia PENG Xiangzhu YAN Jiasi LIU Xiaopeng ZHONG Simin YAO Yiyan MA Shuhua TAN Research progress on female reproductive toxicity of bisphenols 环境与职业医学 bisphenols female reproductive system endocrine disruption reproductive toxicity |
| title | Research progress on female reproductive toxicity of bisphenols |
| title_full | Research progress on female reproductive toxicity of bisphenols |
| title_fullStr | Research progress on female reproductive toxicity of bisphenols |
| title_full_unstemmed | Research progress on female reproductive toxicity of bisphenols |
| title_short | Research progress on female reproductive toxicity of bisphenols |
| title_sort | research progress on female reproductive toxicity of bisphenols |
| topic | bisphenols female reproductive system endocrine disruption reproductive toxicity |
| url | http://www.jeom.org/article/cn/10.11836/JEOM24493 |
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