Pro-inflammatory mediator and cancer-associated chemokine CXCL8 as a prognostic indicator of tumor aggressiveness, angiogenesis, and disease progression with focus on therapeutic implications and recurrence monitoring
Background: Oral Squamous Cell Carcinoma (OSCC) is a prevalent malignancy characterized by high morbidity and mortality. Chronic inflammation within the tumor microenvironment plays a pivotal role in OSCC progression, with CXCL8 or interleukin-8 (IL-8) emerging as a significant cytokine implicated i...
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Elsevier
2025-03-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906025000111 |
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| author | Hema Shree K Gayathri R Vishnu Priya Veeraraghavan Selvaraj J Pratibha Ramani |
| author_facet | Hema Shree K Gayathri R Vishnu Priya Veeraraghavan Selvaraj J Pratibha Ramani |
| author_sort | Hema Shree K |
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| description | Background: Oral Squamous Cell Carcinoma (OSCC) is a prevalent malignancy characterized by high morbidity and mortality. Chronic inflammation within the tumor microenvironment plays a pivotal role in OSCC progression, with CXCL8 or interleukin-8 (IL-8) emerging as a significant cytokine implicated in various pro-tumorigenic processes. IL-8 promotes angiogenesis, immune evasion, and cancer cell stemness, contributing to tumor aggression and resistance to therapy. Understanding longitudinal changes in IL-8 expression provides insights into OSCC progression and treatment responses, potentially guiding personalized therapeutic strategies. Objectives: To investigate longitudinal trends in IL-8 expression among OSCC patients. To assess correlations between IL-8 levels and disease progression, treatment outcomes, and patient survival. To evaluate IL-8's prognostic value as a biomarker and its potential as a therapeutic target. Methods: A prospective longitudinal study enrolled 75 OSCC patients divided into pre-treatment, post-treatment, and follow-up groups. Saliva samples were collected, and IL-8 expression levels were quantified using RT-PCR and ELISA. Temporal trends in IL-8 expression and associations with clinical outcomes were analyzed using mixed-effects models and Kaplan-Meier survival analysis. Results: Significant elevation of IL-8 levels was observed in OSCC patients compared to controls. IL-8 levels decreased post-treatment but remained elevated compared to controls, with higher levels correlating with advanced tumor stages and poorer differentiation. Kaplan-Meier analysis demonstrated reduced survival probabilities in patients with persistently high IL-8 expression. Conclusions: Longitudinal monitoring of IL-8 expression offers valuable insights into OSCC pathogenesis and treatment response. IL-8's role as a prognostic biomarker and therapeutic target warrants further exploration to enhance disease management and patient outcomes. |
| format | Article |
| id | doaj-art-43a054acef8744d9917b985edc3ca632 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-43a054acef8744d9917b985edc3ca6322025-08-20T03:42:44ZengElsevierOral Oncology Reports2772-90602025-03-011310072310.1016/j.oor.2025.100723Pro-inflammatory mediator and cancer-associated chemokine CXCL8 as a prognostic indicator of tumor aggressiveness, angiogenesis, and disease progression with focus on therapeutic implications and recurrence monitoringHema Shree K0Gayathri R1Vishnu Priya Veeraraghavan2Selvaraj J3Pratibha Ramani4Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute Medical and Technical Science, Saveetha University, Chennai, IndiaDepartment of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute Medical and Technical Science, Saveetha University, Chennai, India; Corresponding author.Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute Medical and Technical Science, Saveetha University, Chennai, IndiaDepartment of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute Medical and Technical Science, Saveetha University, Chennai, IndiaDepartment of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute Medical and Technical Science, Saveetha University, Chennai, IndiaBackground: Oral Squamous Cell Carcinoma (OSCC) is a prevalent malignancy characterized by high morbidity and mortality. Chronic inflammation within the tumor microenvironment plays a pivotal role in OSCC progression, with CXCL8 or interleukin-8 (IL-8) emerging as a significant cytokine implicated in various pro-tumorigenic processes. IL-8 promotes angiogenesis, immune evasion, and cancer cell stemness, contributing to tumor aggression and resistance to therapy. Understanding longitudinal changes in IL-8 expression provides insights into OSCC progression and treatment responses, potentially guiding personalized therapeutic strategies. Objectives: To investigate longitudinal trends in IL-8 expression among OSCC patients. To assess correlations between IL-8 levels and disease progression, treatment outcomes, and patient survival. To evaluate IL-8's prognostic value as a biomarker and its potential as a therapeutic target. Methods: A prospective longitudinal study enrolled 75 OSCC patients divided into pre-treatment, post-treatment, and follow-up groups. Saliva samples were collected, and IL-8 expression levels were quantified using RT-PCR and ELISA. Temporal trends in IL-8 expression and associations with clinical outcomes were analyzed using mixed-effects models and Kaplan-Meier survival analysis. Results: Significant elevation of IL-8 levels was observed in OSCC patients compared to controls. IL-8 levels decreased post-treatment but remained elevated compared to controls, with higher levels correlating with advanced tumor stages and poorer differentiation. Kaplan-Meier analysis demonstrated reduced survival probabilities in patients with persistently high IL-8 expression. Conclusions: Longitudinal monitoring of IL-8 expression offers valuable insights into OSCC pathogenesis and treatment response. IL-8's role as a prognostic biomarker and therapeutic target warrants further exploration to enhance disease management and patient outcomes.http://www.sciencedirect.com/science/article/pii/S2772906025000111IL-8OSCCPrognostic biomarkerKaplan Meier analysisELISA |
| spellingShingle | Hema Shree K Gayathri R Vishnu Priya Veeraraghavan Selvaraj J Pratibha Ramani Pro-inflammatory mediator and cancer-associated chemokine CXCL8 as a prognostic indicator of tumor aggressiveness, angiogenesis, and disease progression with focus on therapeutic implications and recurrence monitoring Oral Oncology Reports IL-8 OSCC Prognostic biomarker Kaplan Meier analysis ELISA |
| title | Pro-inflammatory mediator and cancer-associated chemokine CXCL8 as a prognostic indicator of tumor aggressiveness, angiogenesis, and disease progression with focus on therapeutic implications and recurrence monitoring |
| title_full | Pro-inflammatory mediator and cancer-associated chemokine CXCL8 as a prognostic indicator of tumor aggressiveness, angiogenesis, and disease progression with focus on therapeutic implications and recurrence monitoring |
| title_fullStr | Pro-inflammatory mediator and cancer-associated chemokine CXCL8 as a prognostic indicator of tumor aggressiveness, angiogenesis, and disease progression with focus on therapeutic implications and recurrence monitoring |
| title_full_unstemmed | Pro-inflammatory mediator and cancer-associated chemokine CXCL8 as a prognostic indicator of tumor aggressiveness, angiogenesis, and disease progression with focus on therapeutic implications and recurrence monitoring |
| title_short | Pro-inflammatory mediator and cancer-associated chemokine CXCL8 as a prognostic indicator of tumor aggressiveness, angiogenesis, and disease progression with focus on therapeutic implications and recurrence monitoring |
| title_sort | pro inflammatory mediator and cancer associated chemokine cxcl8 as a prognostic indicator of tumor aggressiveness angiogenesis and disease progression with focus on therapeutic implications and recurrence monitoring |
| topic | IL-8 OSCC Prognostic biomarker Kaplan Meier analysis ELISA |
| url | http://www.sciencedirect.com/science/article/pii/S2772906025000111 |
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