NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESIS
Role of nitric oxide in the pathogenesis of pulmonary tuberculosis has been studied in 77 patients with new infiltrate pulmonary tuberculosis and 34 patients with fibrous cavernous pulmonary tuberculosis. The level of cumulative and endogenous nitrite depended on the clinical form of tuberculosis: i...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2017-02-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/975 |
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| author | M. E. Dyakova N. P. Alekseeva D. S. Esmedlyaeva T. L. Perova N. N. Petrischev P. K. Yablonskiy |
| author_facet | M. E. Dyakova N. P. Alekseeva D. S. Esmedlyaeva T. L. Perova N. N. Petrischev P. K. Yablonskiy |
| author_sort | M. E. Dyakova |
| collection | DOAJ |
| description | Role of nitric oxide in the pathogenesis of pulmonary tuberculosis has been studied in 77 patients with new infiltrate pulmonary tuberculosis and 34 patients with fibrous cavernous pulmonary tuberculosis. The level of cumulative and endogenous nitrite depended on the clinical form of tuberculosis: in infiltrate pulmonary tuberculosis patients it was within the limits of reference ranges, and in fibrous cavernous pulmonary tuberculosis patients it was significantly lower. Results of statistical analysis point out at the significant homogeneity (monofunctionality) of the set of rates, defining the level of NO metabolites in blood serum in infiltrate pulmonary tuberculosis, namely: impact of adenosine deaminase, levels of α1-protease inhibitor, ceruleoplasmin and age. On the contrary in case of fibrous cavernous pulmonary tuberculosis the diverse (multi-functional) complexes were detected including clinical blood rates providing influence on the reduction of NO level in blood. Nitric oxide in the patients with both clinical forms of tuberculosis correlated with classical markers of system inflammatory response, thus nitric oxide can be regarded as an integral component of inflammatory response with potential evaluation of prognosis of specific lesions during follow-up of changes. |
| format | Article |
| id | doaj-art-439d424e7ca545ee8131b6092bfa4a7c |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2017-02-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-439d424e7ca545ee8131b6092bfa4a7c2025-08-20T01:47:52ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062017-02-01952455010.21292/2075-1230-2017-95-2-45-50975NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESISM. E. Dyakova0N. P. Alekseeva1D. S. Esmedlyaeva2T. L. Perova3N. N. Petrischev4P. K. Yablonskiy5St. Petersburg Research Institute of PhthisiopulmonologySt. Petersburg Research Institute of PhthisiopulmonologySt. Petersburg Research Institute of PhthisiopulmonologySt. Petersburg Research Institute of PhthisiopulmonologyPavlov First Saint Petersburg State Medical UniversitySt. Petersburg Research Institute of PhthisiopulmonologyRole of nitric oxide in the pathogenesis of pulmonary tuberculosis has been studied in 77 patients with new infiltrate pulmonary tuberculosis and 34 patients with fibrous cavernous pulmonary tuberculosis. The level of cumulative and endogenous nitrite depended on the clinical form of tuberculosis: in infiltrate pulmonary tuberculosis patients it was within the limits of reference ranges, and in fibrous cavernous pulmonary tuberculosis patients it was significantly lower. Results of statistical analysis point out at the significant homogeneity (monofunctionality) of the set of rates, defining the level of NO metabolites in blood serum in infiltrate pulmonary tuberculosis, namely: impact of adenosine deaminase, levels of α1-protease inhibitor, ceruleoplasmin and age. On the contrary in case of fibrous cavernous pulmonary tuberculosis the diverse (multi-functional) complexes were detected including clinical blood rates providing influence on the reduction of NO level in blood. Nitric oxide in the patients with both clinical forms of tuberculosis correlated with classical markers of system inflammatory response, thus nitric oxide can be regarded as an integral component of inflammatory response with potential evaluation of prognosis of specific lesions during follow-up of changes.https://www.tibl-journal.com/jour/article/view/975tuberculosissystem inflammatory responsenitric oxidegeneral and endogenous nitritesacute phase reactants |
| spellingShingle | M. E. Dyakova N. P. Alekseeva D. S. Esmedlyaeva T. L. Perova N. N. Petrischev P. K. Yablonskiy NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESIS Туберкулез и болезни лёгких tuberculosis system inflammatory response nitric oxide general and endogenous nitrites acute phase reactants |
| title | NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESIS |
| title_full | NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESIS |
| title_fullStr | NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESIS |
| title_full_unstemmed | NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESIS |
| title_short | NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESIS |
| title_sort | nitric oxide biochemical marker of tuberculosis pathogenesis |
| topic | tuberculosis system inflammatory response nitric oxide general and endogenous nitrites acute phase reactants |
| url | https://www.tibl-journal.com/jour/article/view/975 |
| work_keys_str_mv | AT medyakova nitricoxidebiochemicalmarkeroftuberculosispathogenesis AT npalekseeva nitricoxidebiochemicalmarkeroftuberculosispathogenesis AT dsesmedlyaeva nitricoxidebiochemicalmarkeroftuberculosispathogenesis AT tlperova nitricoxidebiochemicalmarkeroftuberculosispathogenesis AT nnpetrischev nitricoxidebiochemicalmarkeroftuberculosispathogenesis AT pkyablonskiy nitricoxidebiochemicalmarkeroftuberculosispathogenesis |