Polynitrogen Bicyclic and Tricyclic Compounds as PDE4 Inhibitors

We report here two new series of designed PDE4 inhibitors, the first one showing the quinoline scaffold recently investigated by us through a fragment-based drug design strategy, and the second consisting of pyrazolo [1′,5′:1,6]pyrimido[4,5-<i>d</i>]pyridazine derivatives. Both the new s...

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Bibliographic Details
Main Authors: Claudia Vergelli, Agostino Cilibrizzi, Gabriella Guerrini, Fabrizio Melani, Marta Menicatti, Gianluca Bartolucci, Maria Paola Giovannoni, Letizia Crocetti
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Series:Applied Sciences
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Online Access:https://www.mdpi.com/2076-3417/15/15/8678
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