Integration of chromosome conformation and gene expression networks reveals regulatory mechanisms in triple negative breast cancer

Integration of chromosome conformation and gene expression networks reveals regulatory mechanisms in triple negative breast cancer

IntroductionTriple-negative breast cancer (TNBC) accounts for twelve percent of all breast cancer cases, with a survival rate around ten percent lower than ER+/PR+ positive breast cancers. There are limited therapeutic options as these tumors do not respond to hormonal therapy or HER2-targeted treat...

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Bibliographic Details
Main Authors: Helena Reyes-Gopar, Keila Adonai Pérez-Fuentes, Matthew L. Bendall, Enrique Hernández-Lemus
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
triple negative breast cancer
chromosome conformation capture
hi-c
complex networks
regulatory genomics
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1597245/full
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