Single-cell and multi-omics analysis reveals the role of stem cells in prognosis and immunotherapy of lung adenocarcinoma patients

Single-cell and multi-omics analysis reveals the role of stem cells in prognosis and immunotherapy of lung adenocarcinoma patients

BackgroundThe roles of stem cells in lung adenocarcinoma (LUAD) progression and therapeutic resistance have been recognized, yet their impact on patient prognosis and immunotherapy response remains unclear.MethodsSingle-cell RNA sequencing was performed to identify stem cell populations characterize...

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Bibliographic Details
Main Authors: Jianan Zheng, Haoran Lin, Wei Ye, Mingjun Du, Chenjun Huang, Jun Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
lung adenocarcinoma
single-cell sequencing
stem cells
prognostic model
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1634830/full
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