Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3.

Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3.

Drosophila larval growth requires efficient conversion of dietary nutrients into biomass. Lactate dehydrogenase (Ldh) and glycerol-3-phosphate dehydrogenase (Gpdh1) support this larval metabolic program by cooperatively promoting glycolytic flux. Consistent with their cooperative functions, the loss...

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Bibliographic Details
Main Authors: Madhulika Rai, Hongde Li, Robert A Policastro, Robert Pepin, Gabriel E Zentner, Travis Nemkov, Angelo D'Alessandro, Jason M Tennessen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011690
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