Supersulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation

Supersulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation

Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation where CD4+ T lymphocytes play an essential role. Accumulating evidence suggests that immune responses driven by CD4+ T cells are critically regulated by various metabolic pathways including oxidative phosphorylation...

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Main Authors: Shunichi Tayama, Yuya Kitamura, Kyoga Hiraide, Hibiki Suzuki, Jing Li, Ziying Yang, Ryoji Mitsuwaka, Akihisa Kawajiri, Kosuke Sato, Feng Gao, Taku Nakai, Yuko Okuyama, Tadahisa Numakura, Mitsuhiro Yamada, Tomoaki Ida, Masanobu Morita, Takeshi Kawabe, Takaaki Akaike, Naoto Ishii
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease
Cd4 + t cell
cell proliferation
cell cycle
supersulfide metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1506580/full
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