Epigenetics: A link between toxicants and diseases
Summary: Epigenetics is a complex network of molecular mechanisms, including DNA modifications, histone modifications, and non-coding RNA transcripts that influence gene transcription in heritable ways across cells. Over the last decades, epigenetic mechanisms have gained significant attention in th...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225008740 |
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| author | Anna Romanò Christina Pagiatakis Rosalba Gornati Giovanni Bernardini Roberto Papait |
| author_facet | Anna Romanò Christina Pagiatakis Rosalba Gornati Giovanni Bernardini Roberto Papait |
| author_sort | Anna Romanò |
| collection | DOAJ |
| description | Summary: Epigenetics is a complex network of molecular mechanisms, including DNA modifications, histone modifications, and non-coding RNA transcripts that influence gene transcription in heritable ways across cells. Over the last decades, epigenetic mechanisms have gained significant attention in the field of toxicology. Various research groups are investigating the epigenetic impact of toxicants due to their role in mediating the effects of environmental factors on cellular function, in complex diseases, and in explaining adverse effects on offspring. Here, we give an overview of these studies, exploring the intersection of epigenetics and toxicology and focusing on how not only environmental pollutants but also recreational substances, such as tobacco smoke and alcoholic beverages, can impact DNA and histone modifications. |
| format | Article |
| id | doaj-art-43953d37cd9543bd91eaeadf6bb83fce |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-43953d37cd9543bd91eaeadf6bb83fce2025-08-20T03:54:01ZengElsevieriScience2589-00422025-06-0128611261310.1016/j.isci.2025.112613Epigenetics: A link between toxicants and diseasesAnna Romanò0Christina Pagiatakis1Rosalba Gornati2Giovanni Bernardini3Roberto Papait4Department of Biotechnologies and Life Science, University of Insubria, Varese, ItalyDepartment of Biotechnologies and Life Science, University of Insubria, Varese, Italy; Department of Cardiovascular Medicine, IRCCS Humanitas Research Hospital, Rozzano, Milan, ItalyDepartment of Biotechnologies and Life Science, University of Insubria, Varese, ItalyDepartment of Biotechnologies and Life Science, University of Insubria, Varese, ItalyDepartment of Biotechnologies and Life Science, University of Insubria, Varese, Italy; Department of Cardiovascular Medicine, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Corresponding authorSummary: Epigenetics is a complex network of molecular mechanisms, including DNA modifications, histone modifications, and non-coding RNA transcripts that influence gene transcription in heritable ways across cells. Over the last decades, epigenetic mechanisms have gained significant attention in the field of toxicology. Various research groups are investigating the epigenetic impact of toxicants due to their role in mediating the effects of environmental factors on cellular function, in complex diseases, and in explaining adverse effects on offspring. Here, we give an overview of these studies, exploring the intersection of epigenetics and toxicology and focusing on how not only environmental pollutants but also recreational substances, such as tobacco smoke and alcoholic beverages, can impact DNA and histone modifications.http://www.sciencedirect.com/science/article/pii/S2589004225008740DiseaseEnvironmentExposureEpigeneticsToxicology |
| spellingShingle | Anna Romanò Christina Pagiatakis Rosalba Gornati Giovanni Bernardini Roberto Papait Epigenetics: A link between toxicants and diseases iScience Disease Environment Exposure Epigenetics Toxicology |
| title | Epigenetics: A link between toxicants and diseases |
| title_full | Epigenetics: A link between toxicants and diseases |
| title_fullStr | Epigenetics: A link between toxicants and diseases |
| title_full_unstemmed | Epigenetics: A link between toxicants and diseases |
| title_short | Epigenetics: A link between toxicants and diseases |
| title_sort | epigenetics a link between toxicants and diseases |
| topic | Disease Environment Exposure Epigenetics Toxicology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225008740 |
| work_keys_str_mv | AT annaromano epigeneticsalinkbetweentoxicantsanddiseases AT christinapagiatakis epigeneticsalinkbetweentoxicantsanddiseases AT rosalbagornati epigeneticsalinkbetweentoxicantsanddiseases AT giovannibernardini epigeneticsalinkbetweentoxicantsanddiseases AT robertopapait epigeneticsalinkbetweentoxicantsanddiseases |