Prevalence of erectile dysfunction as long-COVID symptom in hospitalized Japanese patients
Abstract Coronavirus disease-2019 (COVID-19) is associated with a wide range of post-acute sequelae. The prevalence of erectile dysfunction (ED) that developed after COVID-19 and the associated underlying factors were analyzed based on a questionnaire survey, COVID-19 Recovery Study II in Japan. A c...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-88904-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849723103404359680 |
|---|---|
| author | Hideaki Kato Nao Ichihara Hiroki Saito Shigeki Fujitani Kohei Ota Yuji Takahashi Toshiyuki Harada Takeshi Hattori Mitsuru Komeya Mariko Hosozawa Yoko Muto Miyuki Hori Arisa Iba Hiroyasu Iso Hiroyasu Iso The COVID-19 Recovery Study II Group |
| author_facet | Hideaki Kato Nao Ichihara Hiroki Saito Shigeki Fujitani Kohei Ota Yuji Takahashi Toshiyuki Harada Takeshi Hattori Mitsuru Komeya Mariko Hosozawa Yoko Muto Miyuki Hori Arisa Iba Hiroyasu Iso Hiroyasu Iso The COVID-19 Recovery Study II Group |
| author_sort | Hideaki Kato |
| collection | DOAJ |
| description | Abstract Coronavirus disease-2019 (COVID-19) is associated with a wide range of post-acute sequelae. The prevalence of erectile dysfunction (ED) that developed after COVID-19 and the associated underlying factors were analyzed based on a questionnaire survey, COVID-19 Recovery Study II in Japan. A case–control study was conducted with those with or without ED one and two years hospitalized with COVID-19 between March and September 2021. Six hundred and nine Japanese men, with a median age of 48 years, were analyzed. During the study period, 116 subjects (19.0%) had erectile dysfunction. The patients with ED responded with less subjective awareness of recovery and high breathless and fatigue scores compared to those without ED. The patients with ED also showed higher Hospital Anxiety and Depression Scale-D (depression) and the EuroQol 5-dimensions 5-level scores for pain/discomfort and anxiety/depression scores compared before COVID-19 infection. Sleep disturbance was suggested to be associated with erectile dysfunction using an exploratory clustering analysis in the one-year survey. There were no associations of COVID-19 severity, reinfection, vaccination frequency, antiviral treatment for COVID-19 with the presence of erectile dysfunction. It was considered that mental support for the subject with erectile dysfunction as a long-COVID symptom is warranted. |
| format | Article |
| id | doaj-art-4391dc11bf4f46fa89cfe1b4ffca2449 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-4391dc11bf4f46fa89cfe1b4ffca24492025-08-20T03:11:07ZengNature PortfolioScientific Reports2045-23222025-02-011511710.1038/s41598-025-88904-6Prevalence of erectile dysfunction as long-COVID symptom in hospitalized Japanese patientsHideaki Kato0Nao Ichihara1Hiroki Saito2Shigeki Fujitani3Kohei Ota4Yuji Takahashi5Toshiyuki Harada6Takeshi Hattori7Mitsuru Komeya8Mariko Hosozawa9Yoko Muto10Miyuki Hori11Arisa Iba12Hiroyasu Iso13Hiroyasu Iso14The COVID-19 Recovery Study II GroupInfection Prevention and Control Department, Yokohama City University HospitalDepartment of Medical Innovation, University of Osaka Graduate School of MedicineDepartment of Emergency and Critical Care Medicine, St. Marianna University School of MedicineDepartment of Emergency and Critical Care Medicine, St. Marianna University School of MedicineDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical & Health Sciences, Hiroshima UniversityDepartment of Emergency and Critical Care Medicine, Hitachi General HospitalCenter for Respiratory Diseases, Japan Community Healthcare Organization, Hokkaido HospitalDepartment of Respiratory Medicine, National Hospital Organization Hokkaido Medical CenterDepartment of Urology, Yokohama City University HospitalInstitute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and MedicineInstitute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and MedicineInstitute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and MedicineInstitute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and MedicineInstitute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and MedicineInstitute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and MedicineAbstract Coronavirus disease-2019 (COVID-19) is associated with a wide range of post-acute sequelae. The prevalence of erectile dysfunction (ED) that developed after COVID-19 and the associated underlying factors were analyzed based on a questionnaire survey, COVID-19 Recovery Study II in Japan. A case–control study was conducted with those with or without ED one and two years hospitalized with COVID-19 between March and September 2021. Six hundred and nine Japanese men, with a median age of 48 years, were analyzed. During the study period, 116 subjects (19.0%) had erectile dysfunction. The patients with ED responded with less subjective awareness of recovery and high breathless and fatigue scores compared to those without ED. The patients with ED also showed higher Hospital Anxiety and Depression Scale-D (depression) and the EuroQol 5-dimensions 5-level scores for pain/discomfort and anxiety/depression scores compared before COVID-19 infection. Sleep disturbance was suggested to be associated with erectile dysfunction using an exploratory clustering analysis in the one-year survey. There were no associations of COVID-19 severity, reinfection, vaccination frequency, antiviral treatment for COVID-19 with the presence of erectile dysfunction. It was considered that mental support for the subject with erectile dysfunction as a long-COVID symptom is warranted.https://doi.org/10.1038/s41598-025-88904-6Coronavirus disease-2019 (COVID-19)Erectile dysfunctionPost-acute sequelaeSleep disorderCOVID-19 Recovery Study II (CORES II) |
| spellingShingle | Hideaki Kato Nao Ichihara Hiroki Saito Shigeki Fujitani Kohei Ota Yuji Takahashi Toshiyuki Harada Takeshi Hattori Mitsuru Komeya Mariko Hosozawa Yoko Muto Miyuki Hori Arisa Iba Hiroyasu Iso Hiroyasu Iso The COVID-19 Recovery Study II Group Prevalence of erectile dysfunction as long-COVID symptom in hospitalized Japanese patients Scientific Reports Coronavirus disease-2019 (COVID-19) Erectile dysfunction Post-acute sequelae Sleep disorder COVID-19 Recovery Study II (CORES II) |
| title | Prevalence of erectile dysfunction as long-COVID symptom in hospitalized Japanese patients |
| title_full | Prevalence of erectile dysfunction as long-COVID symptom in hospitalized Japanese patients |
| title_fullStr | Prevalence of erectile dysfunction as long-COVID symptom in hospitalized Japanese patients |
| title_full_unstemmed | Prevalence of erectile dysfunction as long-COVID symptom in hospitalized Japanese patients |
| title_short | Prevalence of erectile dysfunction as long-COVID symptom in hospitalized Japanese patients |
| title_sort | prevalence of erectile dysfunction as long covid symptom in hospitalized japanese patients |
| topic | Coronavirus disease-2019 (COVID-19) Erectile dysfunction Post-acute sequelae Sleep disorder COVID-19 Recovery Study II (CORES II) |
| url | https://doi.org/10.1038/s41598-025-88904-6 |
| work_keys_str_mv | AT hideakikato prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT naoichihara prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT hirokisaito prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT shigekifujitani prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT koheiota prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT yujitakahashi prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT toshiyukiharada prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT takeshihattori prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT mitsurukomeya prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT marikohosozawa prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT yokomuto prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT miyukihori prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT arisaiba prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT hiroyasuiso prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT hiroyasuiso prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients AT thecovid19recoverystudyiigroup prevalenceoferectiledysfunctionaslongcovidsymptominhospitalizedjapanesepatients |