Pathogenicity and Virulence of Coxiella burnetii: Focus on Q fever
Coxiella burnetii is responsible for Q fever, a zoonosis that mainly manifests as a mild acute infection and may persist in specific individuals causing severe complications, including endocarditis and vascular infections. Transmission mainly occurs through the inhalation of aerosols, underlining ba...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Virulence |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2025.2495842 |
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| _version_ | 1849689300145274880 |
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| author | Soraya Mezouar Benoit Desnues Yassina Bechah Nathalie Bardin Christian Devaux Jean-Louis Mege |
| author_facet | Soraya Mezouar Benoit Desnues Yassina Bechah Nathalie Bardin Christian Devaux Jean-Louis Mege |
| author_sort | Soraya Mezouar |
| collection | DOAJ |
| description | Coxiella burnetii is responsible for Q fever, a zoonosis that mainly manifests as a mild acute infection and may persist in specific individuals causing severe complications, including endocarditis and vascular infections. Transmission mainly occurs through the inhalation of aerosols, underlining bacterial resistance to environmental stress. C. burnetii is an intracellular gram-negative pathogen that can infect and survive in monocytes and macrophages and replicate within acidic compartments. C. burnetii expresses several virulence factors, including lipopolysaccharide and a type IV secretion system, which are involved in hijacking several functions of the immune system and controlling cell death. This review summarizes research on C. burnetii infection from clinical presentation of Q fever to bacterial and host factors of virulence. It compiles immunological data associated with bacterial cure or persistence and discusses a potential link between C. burnetii-macrophage interaction and immune dysregulation of Q fever. |
| format | Article |
| id | doaj-art-438df3cf19f94affbc341b2c948b36d7 |
| institution | DOAJ |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-438df3cf19f94affbc341b2c948b36d72025-08-20T03:21:42ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2025.2495842Pathogenicity and Virulence of Coxiella burnetii: Focus on Q feverSoraya Mezouar0Benoit Desnues1Yassina Bechah2Nathalie Bardin3Christian Devaux4Jean-Louis Mege5Centre National de la Recherche Scientifique, Établissement Français du Sang, Anthropologie Bio-Culturelle, Droit, Éthique et Santé, Aix-Marseille University, Marseille, FranceMEPHI, Aix-Marseille University, Marseille, FranceMEPHI, Aix-Marseille University, Marseille, FranceInstitut National de la Santé et de la Recherche Médicale, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, Centre de Recherche en CardioVasculaire et Nutrition, Aix-Marseille University, Marseille, FranceMEPHI, Aix-Marseille University, Marseille, FranceCentre National de la Recherche Scientifique, Établissement Français du Sang, Anthropologie Bio-Culturelle, Droit, Éthique et Santé, Aix-Marseille University, Marseille, FranceCoxiella burnetii is responsible for Q fever, a zoonosis that mainly manifests as a mild acute infection and may persist in specific individuals causing severe complications, including endocarditis and vascular infections. Transmission mainly occurs through the inhalation of aerosols, underlining bacterial resistance to environmental stress. C. burnetii is an intracellular gram-negative pathogen that can infect and survive in monocytes and macrophages and replicate within acidic compartments. C. burnetii expresses several virulence factors, including lipopolysaccharide and a type IV secretion system, which are involved in hijacking several functions of the immune system and controlling cell death. This review summarizes research on C. burnetii infection from clinical presentation of Q fever to bacterial and host factors of virulence. It compiles immunological data associated with bacterial cure or persistence and discusses a potential link between C. burnetii-macrophage interaction and immune dysregulation of Q fever.https://www.tandfonline.com/doi/10.1080/21505594.2025.2495842Coxiella burnetiiQ fevermacrophagesvirulence factors |
| spellingShingle | Soraya Mezouar Benoit Desnues Yassina Bechah Nathalie Bardin Christian Devaux Jean-Louis Mege Pathogenicity and Virulence of Coxiella burnetii: Focus on Q fever Virulence Coxiella burnetii Q fever macrophages virulence factors |
| title | Pathogenicity and Virulence of Coxiella burnetii: Focus on Q fever |
| title_full | Pathogenicity and Virulence of Coxiella burnetii: Focus on Q fever |
| title_fullStr | Pathogenicity and Virulence of Coxiella burnetii: Focus on Q fever |
| title_full_unstemmed | Pathogenicity and Virulence of Coxiella burnetii: Focus on Q fever |
| title_short | Pathogenicity and Virulence of Coxiella burnetii: Focus on Q fever |
| title_sort | pathogenicity and virulence of coxiella burnetii focus on q fever |
| topic | Coxiella burnetii Q fever macrophages virulence factors |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2025.2495842 |
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