Prenatal Predictors and Early Postnatal Outcomes in Fetuses Diagnosed with Tricuspid Atresia
<b>Objective:</b> To assess the prenatal course and early postnatal outcomes of fetuses diagnosed with tricuspid atresia and to identify predictors of survival. <b>Methods:</b> This was a retrospective study of 25 fetuses diagnosed with tricuspid atresia in a single tertiary...
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MDPI AG
2024-12-01
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| author | Ozge Kahramanoglu Omer Gokhan Eyisoy Oya Demirci |
| author_facet | Ozge Kahramanoglu Omer Gokhan Eyisoy Oya Demirci |
| author_sort | Ozge Kahramanoglu |
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| description | <b>Objective:</b> To assess the prenatal course and early postnatal outcomes of fetuses diagnosed with tricuspid atresia and to identify predictors of survival. <b>Methods:</b> This was a retrospective study of 25 fetuses diagnosed with tricuspid atresia in a single tertiary referral center, evaluating prenatal echocardiographic features and postnatal outcomes. <b>Results:</b> A total of 4 of 29 initially diagnosed fetuses were excluded due to changes in diagnosis or loss to follow-up, leaving 25 fetuses for analysis. Of these, 16 (64%) had concordant VA alignment, 8 (32%) had discordant VA connections, and 1 had a double-outlet left ventricle (DOLV). Pulmonary stenosis was observed in 13 fetuses, and 10 (40%) had extracardiac anomalies. Genetic testing, performed in 5 cases, identified a chromosomal anomaly in one case (trisomy 18). Overall, three pregnancies were terminated due to severe associated anomalies. Among the 22 liveborn infants, survival at 12 months was 72%. Restrictive ventricular septal defect (VSD) and the high ductus venosus pulsatility index were significantly associated with lower survival (<i>p</i> = 0.021 and <i>p</i> = 0.034, respectively). <b>Conclusions:</b> Tricuspid atresia can be accurately diagnosed in utero with a thorough echocardiographic evaluation. Restrictive VSD and outflow tract obstructions are critical determinants of early survival, while abnormal DV Doppler patterns may serve as additional markers for adverse outcomes. More extensive studies are needed to validate these findings and improve prognostic counseling. |
| format | Article |
| id | doaj-art-4388e578be734bfc9e7ff98ddd940ff6 |
| institution | DOAJ |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-4388e578be734bfc9e7ff98ddd940ff62025-08-20T02:55:52ZengMDPI AGDiagnostics2075-44182024-12-011424285510.3390/diagnostics14242855Prenatal Predictors and Early Postnatal Outcomes in Fetuses Diagnosed with Tricuspid AtresiaOzge Kahramanoglu0Omer Gokhan Eyisoy1Oya Demirci2Zeynep Kamil Women and Children’s Diseases Training and Research Hospital, Department of Perinatology, Health Science University, Istanbul 34668, TurkeyZeynep Kamil Women and Children’s Diseases Training and Research Hospital, Department of Perinatology, Health Science University, Istanbul 34668, TurkeyZeynep Kamil Women and Children’s Diseases Training and Research Hospital, Department of Perinatology, Health Science University, Istanbul 34668, Turkey<b>Objective:</b> To assess the prenatal course and early postnatal outcomes of fetuses diagnosed with tricuspid atresia and to identify predictors of survival. <b>Methods:</b> This was a retrospective study of 25 fetuses diagnosed with tricuspid atresia in a single tertiary referral center, evaluating prenatal echocardiographic features and postnatal outcomes. <b>Results:</b> A total of 4 of 29 initially diagnosed fetuses were excluded due to changes in diagnosis or loss to follow-up, leaving 25 fetuses for analysis. Of these, 16 (64%) had concordant VA alignment, 8 (32%) had discordant VA connections, and 1 had a double-outlet left ventricle (DOLV). Pulmonary stenosis was observed in 13 fetuses, and 10 (40%) had extracardiac anomalies. Genetic testing, performed in 5 cases, identified a chromosomal anomaly in one case (trisomy 18). Overall, three pregnancies were terminated due to severe associated anomalies. Among the 22 liveborn infants, survival at 12 months was 72%. Restrictive ventricular septal defect (VSD) and the high ductus venosus pulsatility index were significantly associated with lower survival (<i>p</i> = 0.021 and <i>p</i> = 0.034, respectively). <b>Conclusions:</b> Tricuspid atresia can be accurately diagnosed in utero with a thorough echocardiographic evaluation. Restrictive VSD and outflow tract obstructions are critical determinants of early survival, while abnormal DV Doppler patterns may serve as additional markers for adverse outcomes. More extensive studies are needed to validate these findings and improve prognostic counseling.https://www.mdpi.com/2075-4418/14/24/2855Dopplerechocardiographypulmonary stenosistricuspid atresiaventricular septal defect |
| spellingShingle | Ozge Kahramanoglu Omer Gokhan Eyisoy Oya Demirci Prenatal Predictors and Early Postnatal Outcomes in Fetuses Diagnosed with Tricuspid Atresia Diagnostics Doppler echocardiography pulmonary stenosis tricuspid atresia ventricular septal defect |
| title | Prenatal Predictors and Early Postnatal Outcomes in Fetuses Diagnosed with Tricuspid Atresia |
| title_full | Prenatal Predictors and Early Postnatal Outcomes in Fetuses Diagnosed with Tricuspid Atresia |
| title_fullStr | Prenatal Predictors and Early Postnatal Outcomes in Fetuses Diagnosed with Tricuspid Atresia |
| title_full_unstemmed | Prenatal Predictors and Early Postnatal Outcomes in Fetuses Diagnosed with Tricuspid Atresia |
| title_short | Prenatal Predictors and Early Postnatal Outcomes in Fetuses Diagnosed with Tricuspid Atresia |
| title_sort | prenatal predictors and early postnatal outcomes in fetuses diagnosed with tricuspid atresia |
| topic | Doppler echocardiography pulmonary stenosis tricuspid atresia ventricular septal defect |
| url | https://www.mdpi.com/2075-4418/14/24/2855 |
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