Mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia
Abstract Whether the role of gut microbial features lies in the pathways from lifestyles to dyslipidemia remains unclear. In this cross-sectional study, we conducted a metagenome-wide association analysis and fecal metabolomic profiling in 994 adults from the China Multi-Ethnic cohort. A total of 26...
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| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-025-00721-x |
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| author | Lijun Zeng Bin Yu Peibin Zeng Zhuoma Duoji Haojiang Zuo Jian Lian Tingting Yang Yingxue Dai Yuemei Feng Peng Yu Jiqi Yang Shujuan Yang Qingyu Dou |
| author_facet | Lijun Zeng Bin Yu Peibin Zeng Zhuoma Duoji Haojiang Zuo Jian Lian Tingting Yang Yingxue Dai Yuemei Feng Peng Yu Jiqi Yang Shujuan Yang Qingyu Dou |
| author_sort | Lijun Zeng |
| collection | DOAJ |
| description | Abstract Whether the role of gut microbial features lies in the pathways from lifestyles to dyslipidemia remains unclear. In this cross-sectional study, we conducted a metagenome-wide association analysis and fecal metabolomic profiling in 994 adults from the China Multi-Ethnic cohort. A total of 26 microbial species were identified as mediators between lifestyle factors and risk for dyslipidemia. Specifically, the abundance of [Ruminococcus] gnavus mediated the associations between lifestyles and risks for dyslipidemia, elevated low-density lipoprotein cholesterol, elevated total cholesterol, and elevated triglycerides. [Ruminococcus] gnavus, Alistipes shahii, and Lachnospira eligens were replicated to be associated with dyslipidemia in an external validation cohort. The potential metabolic pathways included arachidonic acid, bile acid, and aromatic amino-acid metabolism. |
| format | Article |
| id | doaj-art-43844a2c84014bfaac20efae318ddf98 |
| institution | DOAJ |
| issn | 2055-5008 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-43844a2c84014bfaac20efae318ddf982025-08-20T03:22:11ZengNature Portfolionpj Biofilms and Microbiomes2055-50082025-05-0111111110.1038/s41522-025-00721-xMediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemiaLijun Zeng0Bin Yu1Peibin Zeng2Zhuoma Duoji3Haojiang Zuo4Jian Lian5Tingting Yang6Yingxue Dai7Yuemei Feng8Peng Yu9Jiqi Yang10Shujuan Yang11Qingyu Dou12Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityHigh Altitude Medical Research Center, School of Medicine, Tibet UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityInstitute of Chronic Non-Communicable Disease Control and Prevention, Chongqing Center for Disease Control and PreventionSchool of Public Health, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical UniversityChengdu Center for Disease Control and PreventionSchool of Public Health, Kunming Medical UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityNational Clinical Research Center for Geriatrics, Center of Gerontology and Geriatrics, West China Hospital, Sichuan UniversityAbstract Whether the role of gut microbial features lies in the pathways from lifestyles to dyslipidemia remains unclear. In this cross-sectional study, we conducted a metagenome-wide association analysis and fecal metabolomic profiling in 994 adults from the China Multi-Ethnic cohort. A total of 26 microbial species were identified as mediators between lifestyle factors and risk for dyslipidemia. Specifically, the abundance of [Ruminococcus] gnavus mediated the associations between lifestyles and risks for dyslipidemia, elevated low-density lipoprotein cholesterol, elevated total cholesterol, and elevated triglycerides. [Ruminococcus] gnavus, Alistipes shahii, and Lachnospira eligens were replicated to be associated with dyslipidemia in an external validation cohort. The potential metabolic pathways included arachidonic acid, bile acid, and aromatic amino-acid metabolism.https://doi.org/10.1038/s41522-025-00721-x |
| spellingShingle | Lijun Zeng Bin Yu Peibin Zeng Zhuoma Duoji Haojiang Zuo Jian Lian Tingting Yang Yingxue Dai Yuemei Feng Peng Yu Jiqi Yang Shujuan Yang Qingyu Dou Mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia npj Biofilms and Microbiomes |
| title | Mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia |
| title_full | Mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia |
| title_fullStr | Mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia |
| title_full_unstemmed | Mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia |
| title_short | Mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia |
| title_sort | mediation effect and metabolic pathways of gut microbiota in the associations between lifestyles and dyslipidemia |
| url | https://doi.org/10.1038/s41522-025-00721-x |
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