The neuroscience of cancer: Focus on neuropeptidergic systems
Tumors are complex, highly heterogeneous diseases that place an enormous burden on the world's healthcare systems. Updating understanding of tumor initiation and progression is critical and the current breakthrough lies in cancer neuroscience, which focuses on the crosstalk between neural compo...
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Elsevier
2025-05-01
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| Series: | Acta Pharmaceutica Sinica B |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383525001625 |
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| author | Zikai Dong Yongfei Wang Weilin Jin |
| author_facet | Zikai Dong Yongfei Wang Weilin Jin |
| author_sort | Zikai Dong |
| collection | DOAJ |
| description | Tumors are complex, highly heterogeneous diseases that place an enormous burden on the world's healthcare systems. Updating understanding of tumor initiation and progression is critical and the current breakthrough lies in cancer neuroscience, which focuses on the crosstalk between neural components and tumors. Neuropeptides are a class of highly potent peptides, that perform the physiological functions of neurotransmitters, neuromodulators, and endocrine hormones. Currently, many studies have shown that many cellular components of the tumor microenvironment express neuropeptides and their receptors and that neuropeptides may play an important role in their cellular communication. In addition, neuropeptides and their receptors affect cancer hallmarks such as proliferation, invasion and metastasis, angiogenesis, immune escape, metabolic reprogramming, and others. More importantly, neuropeptides may also affect some tumor comorbidities such as insomnia, depression, anorexia, cancer pain, and others. Targeting neuropeptides in combination with new therapeutic strategies may significantly advance anti-tumor therapy, not only for treating the tumor itself but also for improving the patient's quality of life. |
| format | Article |
| id | doaj-art-438345ec3c6f41be8d7374e4af20f62b |
| institution | OA Journals |
| issn | 2211-3835 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj-art-438345ec3c6f41be8d7374e4af20f62b2025-08-20T01:49:58ZengElsevierActa Pharmaceutica Sinica B2211-38352025-05-011552323235010.1016/j.apsb.2025.03.025The neuroscience of cancer: Focus on neuropeptidergic systemsZikai Dong0Yongfei Wang1Weilin Jin2Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, the First Hospital of Lanzhou University, the First Clinical Medical College of Lanzhou University, Lanzhou 730000, China; The First Clinical Medical College of Lanzhou University, Lanzhou 730000, ChinaInstitute of Cancer Neuroscience, Medical Frontier Innovation Research Center, the First Hospital of Lanzhou University, the First Clinical Medical College of Lanzhou University, Lanzhou 730000, China; The First Clinical Medical College of Lanzhou University, Lanzhou 730000, ChinaInstitute of Cancer Neuroscience, Medical Frontier Innovation Research Center, the First Hospital of Lanzhou University, the First Clinical Medical College of Lanzhou University, Lanzhou 730000, China; The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China; Corresponding author.Tumors are complex, highly heterogeneous diseases that place an enormous burden on the world's healthcare systems. Updating understanding of tumor initiation and progression is critical and the current breakthrough lies in cancer neuroscience, which focuses on the crosstalk between neural components and tumors. Neuropeptides are a class of highly potent peptides, that perform the physiological functions of neurotransmitters, neuromodulators, and endocrine hormones. Currently, many studies have shown that many cellular components of the tumor microenvironment express neuropeptides and their receptors and that neuropeptides may play an important role in their cellular communication. In addition, neuropeptides and their receptors affect cancer hallmarks such as proliferation, invasion and metastasis, angiogenesis, immune escape, metabolic reprogramming, and others. More importantly, neuropeptides may also affect some tumor comorbidities such as insomnia, depression, anorexia, cancer pain, and others. Targeting neuropeptides in combination with new therapeutic strategies may significantly advance anti-tumor therapy, not only for treating the tumor itself but also for improving the patient's quality of life.http://www.sciencedirect.com/science/article/pii/S2211383525001625Cancer neuroscienceDrug repurposingComorbidityGPCRsNeuropeptidesTargeted therapy |
| spellingShingle | Zikai Dong Yongfei Wang Weilin Jin The neuroscience of cancer: Focus on neuropeptidergic systems Acta Pharmaceutica Sinica B Cancer neuroscience Drug repurposing Comorbidity GPCRs Neuropeptides Targeted therapy |
| title | The neuroscience of cancer: Focus on neuropeptidergic systems |
| title_full | The neuroscience of cancer: Focus on neuropeptidergic systems |
| title_fullStr | The neuroscience of cancer: Focus on neuropeptidergic systems |
| title_full_unstemmed | The neuroscience of cancer: Focus on neuropeptidergic systems |
| title_short | The neuroscience of cancer: Focus on neuropeptidergic systems |
| title_sort | neuroscience of cancer focus on neuropeptidergic systems |
| topic | Cancer neuroscience Drug repurposing Comorbidity GPCRs Neuropeptides Targeted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2211383525001625 |
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