Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral Sclerosis
Background and Objectives. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons in the brainstem, motor cortex, and spinal cord. Oxidative stress and neuroinflammation have been implicated in the pathophysiology of ALS. Members of the...
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| Format: | Article |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/421389 |
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| author | Guan-Ting Liu Chi-Shin Hwang Chia-Hung Hsieh Chih-Hao Lu Sunny Li-Yun Chang Jin-Ching Lee Chien-Fu Huang Hao-Teng Chang |
| author_facet | Guan-Ting Liu Chi-Shin Hwang Chia-Hung Hsieh Chih-Hao Lu Sunny Li-Yun Chang Jin-Ching Lee Chien-Fu Huang Hao-Teng Chang |
| author_sort | Guan-Ting Liu |
| collection | DOAJ |
| description | Background and Objectives. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons in the brainstem, motor cortex, and spinal cord. Oxidative stress and neuroinflammation have been implicated in the pathophysiology of ALS. Members of the family of damage-associated molecular patterns, including reactive oxygen species, high-mobility group box 1, and eosinophil-derived neurotoxin (EDN), may participate in pathological conditions. In this study, we aim to discover new biomarker for detecting ALS. Materials and Methods. We examined 44 patients with ALS, 41 patients with Alzheimer’s disease, 41 patients with Parkinson’s disease, and 44 healthy controls. The concentration of serum EDN was measured using an enzyme-linked immunosorbent assay. Results. EDN levels were significantly increased 2.17-fold in the serum of patients with ALS as compared with healthy controls (P<0.05). No correlation between the levels of serum EDN and various clinical parameters of ALS was found. Moreover, the levels of serum EDN in patients with Parkinson’s disease and Alzheimer’s disease and healthy controls were similar. Conclusion. A higher level of serum EDN was found specifically in patients with ALS, indicating that EDN may participate in the pathophysiology of ALS. |
| format | Article |
| id | doaj-art-4382ff3d879e4149bd1c193da717598c |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4382ff3d879e4149bd1c193da717598c2025-08-20T02:37:59ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/421389421389Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral SclerosisGuan-Ting Liu0Chi-Shin Hwang1Chia-Hung Hsieh2Chih-Hao Lu3Sunny Li-Yun Chang4Jin-Ching Lee5Chien-Fu Huang6Hao-Teng Chang7Graduate Institute of Molecular Systems Biomedicine, College of Medicine, China Medical University, Taichung 40402, TaiwanDepartment of Neurology, Taipei City Hospital, Zhongxiao Branch, Taipei 11556, TaiwanGraduate Institute of Basic Medical Science and Ph.D. Program for Aging, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, TaiwanGraduate Institute of Molecular Systems Biomedicine, College of Medicine, China Medical University, Taichung 40402, TaiwanGraduate Institute of Molecular Systems Biomedicine, College of Medicine, China Medical University, Taichung 40402, TaiwanDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Biological Science and Technology, I-Shou University, Kaohsiung 82445, TaiwanGraduate Institute of Molecular Systems Biomedicine, College of Medicine, China Medical University, Taichung 40402, TaiwanBackground and Objectives. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons in the brainstem, motor cortex, and spinal cord. Oxidative stress and neuroinflammation have been implicated in the pathophysiology of ALS. Members of the family of damage-associated molecular patterns, including reactive oxygen species, high-mobility group box 1, and eosinophil-derived neurotoxin (EDN), may participate in pathological conditions. In this study, we aim to discover new biomarker for detecting ALS. Materials and Methods. We examined 44 patients with ALS, 41 patients with Alzheimer’s disease, 41 patients with Parkinson’s disease, and 44 healthy controls. The concentration of serum EDN was measured using an enzyme-linked immunosorbent assay. Results. EDN levels were significantly increased 2.17-fold in the serum of patients with ALS as compared with healthy controls (P<0.05). No correlation between the levels of serum EDN and various clinical parameters of ALS was found. Moreover, the levels of serum EDN in patients with Parkinson’s disease and Alzheimer’s disease and healthy controls were similar. Conclusion. A higher level of serum EDN was found specifically in patients with ALS, indicating that EDN may participate in the pathophysiology of ALS.http://dx.doi.org/10.1155/2013/421389 |
| spellingShingle | Guan-Ting Liu Chi-Shin Hwang Chia-Hung Hsieh Chih-Hao Lu Sunny Li-Yun Chang Jin-Ching Lee Chien-Fu Huang Hao-Teng Chang Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral Sclerosis Mediators of Inflammation |
| title | Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral Sclerosis |
| title_full | Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral Sclerosis |
| title_fullStr | Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral Sclerosis |
| title_short | Eosinophil-Derived Neurotoxin Is Elevated in Patients with Amyotrophic Lateral Sclerosis |
| title_sort | eosinophil derived neurotoxin is elevated in patients with amyotrophic lateral sclerosis |
| url | http://dx.doi.org/10.1155/2013/421389 |
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