Magnetic Resonance Thermometry of Focused Ultrasound Using a Preclinical Focused Ultrasound Robotic System at 3T
Aim: Focused ultrasound (FUS) therapies are often performed within magnetic resonance imaging (MRI) systems providing thermometry-based temperature monitoring. Herein, MRI thermometry was assessed for FUS sonications executed using a preclinical system on agar-based phantoms at 1.5T and 3T MRI scann...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Medical Physics |
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| Online Access: | https://journals.lww.com/10.4103/jmp.jmp_133_24 |
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| author | Antria Filippou Nikolas Evripidou Andreas Georgiou Leonidas Georgiou Antreas Chrysanthou Cleanthis Ioannides Christakis Damianou |
| author_facet | Antria Filippou Nikolas Evripidou Andreas Georgiou Leonidas Georgiou Antreas Chrysanthou Cleanthis Ioannides Christakis Damianou |
| author_sort | Antria Filippou |
| collection | DOAJ |
| description | Aim:
Focused ultrasound (FUS) therapies are often performed within magnetic resonance imaging (MRI) systems providing thermometry-based temperature monitoring. Herein, MRI thermometry was assessed for FUS sonications executed using a preclinical system on agar-based phantoms at 1.5T and 3T MRI scanners, using the proton resonance frequency shift technique.
Materials and Methods:
Sonications were executed at 1.5T and 3T to assess the system and observe variations in magnetic resonance (MR) thermometry temperature measurements. MR thermometry was assessed at 3T, for identical sonications on three agar-based phantoms doped with varied silica and evaporated milk concentrations, and for sonications executed at varied acoustic power of 1.5–45 W. Moreover, echo time (TE) values of 5–20 ms were used to assess the effect on the signal-to-noise ratio (SNR) and temperature change sensitivity.
Results:
Clearer thermal maps with a 2.5-fold higher temporal resolution were produced for sonications at 3T compared to 1.5T, despite employment of similar thermometry sequences. At 3T, temperature changes between 41°C and 50°C were recorded for the three phantoms produced with varied silica and evaporated milk, with the addition of 2% w/v silica resulting in a 20% increase in temperature change. The lowest acoustic power that produced reliable beam detection within a voxel was 1.5 W. A TE of 10 ms resulted in the highest temperature sensitivity with adequate SNR.
Conclusions:
MR thermometry performed at 3T achieved short temporal resolution with temperature dependencies exhibited with the sonication and imaging parameters. Present data could be used in preclinical MRI-guided FUS feasibility studies to enhance MR thermometry. |
| format | Article |
| id | doaj-art-437ce70066194fcd904b453ceb0c6e3f |
| institution | Kabale University |
| issn | 0971-6203 1998-3913 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Medical Physics |
| spelling | doaj-art-437ce70066194fcd904b453ceb0c6e3f2025-01-07T07:19:03ZengWolters Kluwer Medknow PublicationsJournal of Medical Physics0971-62031998-39132024-12-0149458359610.4103/jmp.jmp_133_24Magnetic Resonance Thermometry of Focused Ultrasound Using a Preclinical Focused Ultrasound Robotic System at 3TAntria FilippouNikolas EvripidouAndreas GeorgiouLeonidas GeorgiouAntreas ChrysanthouCleanthis IoannidesChristakis DamianouAim: Focused ultrasound (FUS) therapies are often performed within magnetic resonance imaging (MRI) systems providing thermometry-based temperature monitoring. Herein, MRI thermometry was assessed for FUS sonications executed using a preclinical system on agar-based phantoms at 1.5T and 3T MRI scanners, using the proton resonance frequency shift technique. Materials and Methods: Sonications were executed at 1.5T and 3T to assess the system and observe variations in magnetic resonance (MR) thermometry temperature measurements. MR thermometry was assessed at 3T, for identical sonications on three agar-based phantoms doped with varied silica and evaporated milk concentrations, and for sonications executed at varied acoustic power of 1.5–45 W. Moreover, echo time (TE) values of 5–20 ms were used to assess the effect on the signal-to-noise ratio (SNR) and temperature change sensitivity. Results: Clearer thermal maps with a 2.5-fold higher temporal resolution were produced for sonications at 3T compared to 1.5T, despite employment of similar thermometry sequences. At 3T, temperature changes between 41°C and 50°C were recorded for the three phantoms produced with varied silica and evaporated milk, with the addition of 2% w/v silica resulting in a 20% increase in temperature change. The lowest acoustic power that produced reliable beam detection within a voxel was 1.5 W. A TE of 10 ms resulted in the highest temperature sensitivity with adequate SNR. Conclusions: MR thermometry performed at 3T achieved short temporal resolution with temperature dependencies exhibited with the sonication and imaging parameters. Present data could be used in preclinical MRI-guided FUS feasibility studies to enhance MR thermometry.https://journals.lww.com/10.4103/jmp.jmp_133_24agarmagnetic resonance imagingthermometryultrasound |
| spellingShingle | Antria Filippou Nikolas Evripidou Andreas Georgiou Leonidas Georgiou Antreas Chrysanthou Cleanthis Ioannides Christakis Damianou Magnetic Resonance Thermometry of Focused Ultrasound Using a Preclinical Focused Ultrasound Robotic System at 3T Journal of Medical Physics agar magnetic resonance imaging thermometry ultrasound |
| title | Magnetic Resonance Thermometry of Focused Ultrasound Using a Preclinical Focused Ultrasound Robotic System at 3T |
| title_full | Magnetic Resonance Thermometry of Focused Ultrasound Using a Preclinical Focused Ultrasound Robotic System at 3T |
| title_fullStr | Magnetic Resonance Thermometry of Focused Ultrasound Using a Preclinical Focused Ultrasound Robotic System at 3T |
| title_full_unstemmed | Magnetic Resonance Thermometry of Focused Ultrasound Using a Preclinical Focused Ultrasound Robotic System at 3T |
| title_short | Magnetic Resonance Thermometry of Focused Ultrasound Using a Preclinical Focused Ultrasound Robotic System at 3T |
| title_sort | magnetic resonance thermometry of focused ultrasound using a preclinical focused ultrasound robotic system at 3t |
| topic | agar magnetic resonance imaging thermometry ultrasound |
| url | https://journals.lww.com/10.4103/jmp.jmp_133_24 |
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