Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies
Dementia is a leading health problem worldwide, with Alzheimer’s disease (AD) representing up to 60% of all dementia cases. A growing interest has recently risen on the potential use of natural molecules in this condition. Curcumin is a polyphenolic compound traditionally used in Indian medicine. Se...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/174282 |
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| author | Natascia Brondino Simona Re Annalisa Boldrini Antonella Cuccomarino Niccolò Lanati Francesco Barale Pierluigi Politi |
| author_facet | Natascia Brondino Simona Re Annalisa Boldrini Antonella Cuccomarino Niccolò Lanati Francesco Barale Pierluigi Politi |
| author_sort | Natascia Brondino |
| collection | DOAJ |
| description | Dementia is a leading health problem worldwide, with Alzheimer’s disease (AD) representing up to 60% of all dementia cases. A growing interest has recently risen on the potential use of natural molecules in this condition. Curcumin is a polyphenolic compound traditionally used in Indian medicine. Several in vitro and in vivo studies have found a protective effect of curcumin in AD. In the present systematic review we aimed to evaluate the state-of-the-art of clinical trials of curcumin in AD. We retrieved three published studies, while there are several ongoing clinical trials. To date there is insufficient evidence to suggest the use of curcumin in dementia patients. Of note, short-term use of curcumin appears to be safe. Several reasons could be responsible for the discrepancy between in vitro and in vivo findings and human trials, such as low bioavailability and poor study design. |
| format | Article |
| id | doaj-art-437b44618d5c420eab45047a99d104d4 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-437b44618d5c420eab45047a99d104d42025-02-03T01:31:02ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/174282174282Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human StudiesNatascia Brondino0Simona Re1Annalisa Boldrini2Antonella Cuccomarino3Niccolò Lanati4Francesco Barale5Pierluigi Politi6Department of Brain and Behavioral Sciences, University of Pavia, Via Bassi 21, 27100 Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Via Bassi 21, 27100 Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Via Bassi 21, 27100 Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Via Bassi 21, 27100 Pavia, ItalyDepartment of Public Health, University of Pavia, Viale Golgi 19, 27100 Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Via Bassi 21, 27100 Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Via Bassi 21, 27100 Pavia, ItalyDementia is a leading health problem worldwide, with Alzheimer’s disease (AD) representing up to 60% of all dementia cases. A growing interest has recently risen on the potential use of natural molecules in this condition. Curcumin is a polyphenolic compound traditionally used in Indian medicine. Several in vitro and in vivo studies have found a protective effect of curcumin in AD. In the present systematic review we aimed to evaluate the state-of-the-art of clinical trials of curcumin in AD. We retrieved three published studies, while there are several ongoing clinical trials. To date there is insufficient evidence to suggest the use of curcumin in dementia patients. Of note, short-term use of curcumin appears to be safe. Several reasons could be responsible for the discrepancy between in vitro and in vivo findings and human trials, such as low bioavailability and poor study design.http://dx.doi.org/10.1155/2014/174282 |
| spellingShingle | Natascia Brondino Simona Re Annalisa Boldrini Antonella Cuccomarino Niccolò Lanati Francesco Barale Pierluigi Politi Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies The Scientific World Journal |
| title | Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies |
| title_full | Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies |
| title_fullStr | Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies |
| title_full_unstemmed | Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies |
| title_short | Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies |
| title_sort | curcumin as a therapeutic agent in dementia a mini systematic review of human studies |
| url | http://dx.doi.org/10.1155/2014/174282 |
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