CD21low B cells reveal a unique glycosylation pattern with hypersialylation and hyperfucosylation

CD21low B cells reveal a unique glycosylation pattern with hypersialylation and hyperfucosylation

BackgroundThe posttranslational modification of cellular macromolecules by glycosylation is considered to contribute to disease pathogenesis in autoimmune and inflammatory conditions. In a subgroup of patients with common variable immunodeficiency (CVID), the occurrence of such complications is asso...

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Bibliographic Details
Main Authors: Peter Tobias Felixberger, Geoffroy Andrieux, Andrea Maul-Pavicic, Sigune Goldacker, Ina Harder, Sylvia Gutenberger, Jonathan J. M. Landry, Vladimir Benes, Till Fabian Jakob, Melanie Boerries, Lars Nitschke, Reinhard Edmund Voll, Klaus Warnatz, Baerbel Keller
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
CD21low B cells
CVID
glycome
glycosylation
hypersialylation
hyperfucosylation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1512279/full
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