Evaluation of Human β-defensin-3 Diagnostic Role in a Group of Iraqi Patients with Osteoporosis
Background: Osteoporosis (OP) is a prevalent age-related condition that increases the risk of fracture and bone fragility, as result loss of bone mass as well as micro-architectural degradation of the bone, thereby reducing the mass and strength of bone. Human β-defensin (HBD-3) is ananti-inflammat...
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College of Medicine University of Baghdad
2024-12-01
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| Series: | مجلة كلية الطب |
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| Online Access: | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2386 |
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| author | Zahraa S. Hassan Layla O. Farhan |
| author_facet | Zahraa S. Hassan Layla O. Farhan |
| author_sort | Zahraa S. Hassan |
| collection | DOAJ |
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Background: Osteoporosis (OP) is a prevalent age-related condition that increases the risk of fracture and bone fragility, as result loss of bone mass as well as micro-architectural degradation of the bone, thereby reducing the mass and strength of bone. Human β-defensin (HBD-3) is ananti-inflammatory peptide andcrucial part of the human innate immune system. Giving early therapeutic intervention for OP requires an early diagnosis.
Objectives: To evaluate the serum HBD-3 accuracy of diagnosis in patients with osteoporosis.
Methods: The study was conducted in the National Joint Center at Yarmouk Teaching Hospital in Baghdad during September - October 2023.
Eighty participants were recruited, all of whom had clinical examinations and had their bone status measured by dual-energy X-ray absorptiometry (DXA). Levels of serum HBD-3 and vitamin D3 (Vit D3) were determined by the ELISA technique. Calcium level (Ca+2) was measured using a spectrophotometer. A comparative study was conducted between forty patients with OP and 40 controls. The study included females and males with an age range between (40-60) years.
Results: The serum level of HBD-3 in the OP group was significantly higher (p < 0.001) than that of the healthy controls. The area under the curve (AUC) was found to be (1.000) in the ROC curve analysis for serum HBD-3 level.
Conclusion: Serum HBD-3 can be a valuable indicator of OP in middle-aged individuals, and may be a helpful biological marker for OP diagnosis.
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| format | Article |
| id | doaj-art-437440cee6a841b9af8e374c074e955e |
| institution | Kabale University |
| issn | 0041-9419 2410-8057 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | College of Medicine University of Baghdad |
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| series | مجلة كلية الطب |
| spelling | doaj-art-437440cee6a841b9af8e374c074e955e2025-01-19T12:24:09ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572024-12-0166410.32007/jfacmedbaghdad.6642386Evaluation of Human β-defensin-3 Diagnostic Role in a Group of Iraqi Patients with OsteoporosisZahraa S. Hassan0https://orcid.org/0009-0007-7350-6423Layla O. Farhan1https://orcid.org/0000-0003-1886-7780Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq.Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq. Background: Osteoporosis (OP) is a prevalent age-related condition that increases the risk of fracture and bone fragility, as result loss of bone mass as well as micro-architectural degradation of the bone, thereby reducing the mass and strength of bone. Human β-defensin (HBD-3) is ananti-inflammatory peptide andcrucial part of the human innate immune system. Giving early therapeutic intervention for OP requires an early diagnosis. Objectives: To evaluate the serum HBD-3 accuracy of diagnosis in patients with osteoporosis. Methods: The study was conducted in the National Joint Center at Yarmouk Teaching Hospital in Baghdad during September - October 2023. Eighty participants were recruited, all of whom had clinical examinations and had their bone status measured by dual-energy X-ray absorptiometry (DXA). Levels of serum HBD-3 and vitamin D3 (Vit D3) were determined by the ELISA technique. Calcium level (Ca+2) was measured using a spectrophotometer. A comparative study was conducted between forty patients with OP and 40 controls. The study included females and males with an age range between (40-60) years. Results: The serum level of HBD-3 in the OP group was significantly higher (p < 0.001) than that of the healthy controls. The area under the curve (AUC) was found to be (1.000) in the ROC curve analysis for serum HBD-3 level. Conclusion: Serum HBD-3 can be a valuable indicator of OP in middle-aged individuals, and may be a helpful biological marker for OP diagnosis. https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2386CalciumHuman β-defensin-3Osteoporosis T-scoreVitamin D3 |
| spellingShingle | Zahraa S. Hassan Layla O. Farhan Evaluation of Human β-defensin-3 Diagnostic Role in a Group of Iraqi Patients with Osteoporosis مجلة كلية الطب Calcium Human β-defensin-3 Osteoporosis T-score Vitamin D3 |
| title | Evaluation of Human β-defensin-3 Diagnostic Role in a Group of Iraqi Patients with Osteoporosis |
| title_full | Evaluation of Human β-defensin-3 Diagnostic Role in a Group of Iraqi Patients with Osteoporosis |
| title_fullStr | Evaluation of Human β-defensin-3 Diagnostic Role in a Group of Iraqi Patients with Osteoporosis |
| title_full_unstemmed | Evaluation of Human β-defensin-3 Diagnostic Role in a Group of Iraqi Patients with Osteoporosis |
| title_short | Evaluation of Human β-defensin-3 Diagnostic Role in a Group of Iraqi Patients with Osteoporosis |
| title_sort | evaluation of human β defensin 3 diagnostic role in a group of iraqi patients with osteoporosis |
| topic | Calcium Human β-defensin-3 Osteoporosis T-score Vitamin D3 |
| url | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2386 |
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