Evaluation of Human β-defensin-3 Diagnostic Role in a Group of Iraqi Patients with Osteoporosis
Background: Osteoporosis (OP) is a prevalent age-related condition that increases the risk of fracture and bone fragility, as result loss of bone mass as well as micro-architectural degradation of the bone, thereby reducing the mass and strength of bone. Human β-defensin (HBD-3) is ananti-inflammat...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Medicine University of Baghdad
2024-12-01
|
| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2386 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background: Osteoporosis (OP) is a prevalent age-related condition that increases the risk of fracture and bone fragility, as result loss of bone mass as well as micro-architectural degradation of the bone, thereby reducing the mass and strength of bone. Human β-defensin (HBD-3) is ananti-inflammatory peptide andcrucial part of the human innate immune system. Giving early therapeutic intervention for OP requires an early diagnosis.
Objectives: To evaluate the serum HBD-3 accuracy of diagnosis in patients with osteoporosis.
Methods: The study was conducted in the National Joint Center at Yarmouk Teaching Hospital in Baghdad during September - October 2023.
Eighty participants were recruited, all of whom had clinical examinations and had their bone status measured by dual-energy X-ray absorptiometry (DXA). Levels of serum HBD-3 and vitamin D3 (Vit D3) were determined by the ELISA technique. Calcium level (Ca+2) was measured using a spectrophotometer. A comparative study was conducted between forty patients with OP and 40 controls. The study included females and males with an age range between (40-60) years.
Results: The serum level of HBD-3 in the OP group was significantly higher (p < 0.001) than that of the healthy controls. The area under the curve (AUC) was found to be (1.000) in the ROC curve analysis for serum HBD-3 level.
Conclusion: Serum HBD-3 can be a valuable indicator of OP in middle-aged individuals, and may be a helpful biological marker for OP diagnosis.
|
|---|---|
| ISSN: | 0041-9419 2410-8057 |