LINC01235 Promotes Clonal Evolution through DNA Replication Licensing‐Induced Chromosomal Instability in Breast Cancer

LINC01235 Promotes Clonal Evolution through DNA Replication Licensing‐Induced Chromosomal Instability in Breast Cancer

Abstract Despite the development of HER2‐targeting drugs such as trastuzumab and T‐DXd, treatment resistance is a substantial challenge, often leading to relapse and distant metastasis. Tumor heterogeneity in HER2‐positive breast cancer drives the evolution of resistant clones following therapeutic...

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Bibliographic Details
Main Authors: Qi Zhang, Xuliren Wang, Zhibo Shao, Yi Zhang, Liyi Zhang, Ming Chen, Xujie Zhou, Han Zhu, Yue Zhou, Xinya Lu, Pei Li, Weiru Chi, Lun Li, Zhi‐Ming Shao, Shenglin Huang, Jingyan Xue, Yayun Chi, Jiong Wu, Bingqiu Xiu
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
ATR inhibitors
chromosomal instabilities
DNA replication licensing
HER2‐positive breast cancers
LINC01235
Online Access:https://doi.org/10.1002/advs.202413527
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