Specific features of regulatory T cells in patients with systemic lupus erythematosus
Regulatory T cells (Tregs) is a CD4+ lymphocyte subpopulation that maintains autotolerance by suppressing the activity of autoreactive lymphocytes. There is a hypothesis that functional defects or a smaller number of Tregs underlie the pathogenesis of a number of autoimmune diseases. The paper consi...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2018-12-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/856 |
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| author | A. V. Torgashina S. К. Solovyev |
| author_facet | A. V. Torgashina S. К. Solovyev |
| author_sort | A. V. Torgashina |
| collection | DOAJ |
| description | Regulatory T cells (Tregs) is a CD4+ lymphocyte subpopulation that maintains autotolerance by suppressing the activity of autoreactive lymphocytes. There is a hypothesis that functional defects or a smaller number of Tregs underlie the pathogenesis of a number of autoimmune diseases. The paper considers the main features of the phenotype of Tregs. It discusses the number of Tregs in both peripheral blood and affected organs in systemic lupus erythematosus, as well as the time course of changes in the level and functional abilities of different subpopulations of Tregs during immunosuppressive therapy. In addition, the paper presents various approaches to using Treg lymphocytes in the therapy of autoimmune diseases. |
| format | Article |
| id | doaj-art-436db1440e034dd9abf92a1e20828a1b |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2018-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-436db1440e034dd9abf92a1e20828a1b2025-08-20T03:01:23ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2018-12-0112491510.14412/1996-7012-2018-4-9-152120Specific features of regulatory T cells in patients with systemic lupus erythematosusA. V. Torgashina0S. К. Solovyev1V.A. Nasonova Research Institute of Rheumatology.V.A. Nasonova Research Institute of Rheumatology.Regulatory T cells (Tregs) is a CD4+ lymphocyte subpopulation that maintains autotolerance by suppressing the activity of autoreactive lymphocytes. There is a hypothesis that functional defects or a smaller number of Tregs underlie the pathogenesis of a number of autoimmune diseases. The paper considers the main features of the phenotype of Tregs. It discusses the number of Tregs in both peripheral blood and affected organs in systemic lupus erythematosus, as well as the time course of changes in the level and functional abilities of different subpopulations of Tregs during immunosuppressive therapy. In addition, the paper presents various approaches to using Treg lymphocytes in the therapy of autoimmune diseases.https://mrj.ima-press.net/mrj/article/view/856regulatory t cells, systemic lupus erythematosus, cytokines |
| spellingShingle | A. V. Torgashina S. К. Solovyev Specific features of regulatory T cells in patients with systemic lupus erythematosus Современная ревматология regulatory t cells, systemic lupus erythematosus, cytokines |
| title | Specific features of regulatory T cells in patients with systemic lupus erythematosus |
| title_full | Specific features of regulatory T cells in patients with systemic lupus erythematosus |
| title_fullStr | Specific features of regulatory T cells in patients with systemic lupus erythematosus |
| title_full_unstemmed | Specific features of regulatory T cells in patients with systemic lupus erythematosus |
| title_short | Specific features of regulatory T cells in patients with systemic lupus erythematosus |
| title_sort | specific features of regulatory t cells in patients with systemic lupus erythematosus |
| topic | regulatory t cells, systemic lupus erythematosus, cytokines |
| url | https://mrj.ima-press.net/mrj/article/view/856 |
| work_keys_str_mv | AT avtorgashina specificfeaturesofregulatorytcellsinpatientswithsystemiclupuserythematosus AT sksolovyev specificfeaturesofregulatorytcellsinpatientswithsystemiclupuserythematosus |