MOLECULAR GENETIC AND IMMUNOLOGICAL ASPECTS OF INVASIVE ASPERGILLOSIS
Aspergillus is very widely spread in nature. Daily people inhale to several thousand spores of micromycetes, however, an effective immune response prevents to development of the disease. In case of violation the mechanisms of innate and adaptive immune response as a result of genetic defects or iatr...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2017-04-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/561 |
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| author | O. V. Shadrivova E. V. Frolova A. Е. Taraskina N. N. Klimko |
| author_facet | O. V. Shadrivova E. V. Frolova A. Е. Taraskina N. N. Klimko |
| author_sort | O. V. Shadrivova |
| collection | DOAJ |
| description | Aspergillus is very widely spread in nature. Daily people inhale to several thousand spores of micromycetes, however, an effective immune response prevents to development of the disease. In case of violation the mechanisms of innate and adaptive immune response as a result of genetic defects or iatrogenic immunosuppression Aspergillus spp. become pathogenic and can cause severe invasive infections in immunocompromised patients. Until now there are no reliable biomarkers for the risk prediction of invasive aspergillosis and monitoring the effectiveness of treatment of infectious process. In our review, we are considering the most important genetic and immunological factors affecting susceptibility to Aspergillus spp., The analysis of which can provide an individual approach to antifungal therapy / prevention in immunocompromised patients. |
| format | Article |
| id | doaj-art-436cf97e3f154185b56e92b7a22d72d1 |
| institution | DOAJ |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2017-04-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-436cf97e3f154185b56e92b7a22d72d12025-08-20T02:55:14ZrusJournal InfectologyЖурнал инфектологии2072-67322017-04-0191475410.22625/2072-6732-2017-9-1-47-54531MOLECULAR GENETIC AND IMMUNOLOGICAL ASPECTS OF INVASIVE ASPERGILLOSISO. V. Shadrivova0E. V. Frolova1A. Е. Taraskina2N. N. Klimko3North-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovAspergillus is very widely spread in nature. Daily people inhale to several thousand spores of micromycetes, however, an effective immune response prevents to development of the disease. In case of violation the mechanisms of innate and adaptive immune response as a result of genetic defects or iatrogenic immunosuppression Aspergillus spp. become pathogenic and can cause severe invasive infections in immunocompromised patients. Until now there are no reliable biomarkers for the risk prediction of invasive aspergillosis and monitoring the effectiveness of treatment of infectious process. In our review, we are considering the most important genetic and immunological factors affecting susceptibility to Aspergillus spp., The analysis of which can provide an individual approach to antifungal therapy / prevention in immunocompromised patients.https://journal.niidi.ru/jofin/article/view/561immune responseaspergillus spp.genetic predispositionimmunologic biomarkersantifungal therapy |
| spellingShingle | O. V. Shadrivova E. V. Frolova A. Е. Taraskina N. N. Klimko MOLECULAR GENETIC AND IMMUNOLOGICAL ASPECTS OF INVASIVE ASPERGILLOSIS Журнал инфектологии immune response aspergillus spp. genetic predisposition immunologic biomarkers antifungal therapy |
| title | MOLECULAR GENETIC AND IMMUNOLOGICAL ASPECTS OF INVASIVE ASPERGILLOSIS |
| title_full | MOLECULAR GENETIC AND IMMUNOLOGICAL ASPECTS OF INVASIVE ASPERGILLOSIS |
| title_fullStr | MOLECULAR GENETIC AND IMMUNOLOGICAL ASPECTS OF INVASIVE ASPERGILLOSIS |
| title_full_unstemmed | MOLECULAR GENETIC AND IMMUNOLOGICAL ASPECTS OF INVASIVE ASPERGILLOSIS |
| title_short | MOLECULAR GENETIC AND IMMUNOLOGICAL ASPECTS OF INVASIVE ASPERGILLOSIS |
| title_sort | molecular genetic and immunological aspects of invasive aspergillosis |
| topic | immune response aspergillus spp. genetic predisposition immunologic biomarkers antifungal therapy |
| url | https://journal.niidi.ru/jofin/article/view/561 |
| work_keys_str_mv | AT ovshadrivova moleculargeneticandimmunologicalaspectsofinvasiveaspergillosis AT evfrolova moleculargeneticandimmunologicalaspectsofinvasiveaspergillosis AT aetaraskina moleculargeneticandimmunologicalaspectsofinvasiveaspergillosis AT nnklimko moleculargeneticandimmunologicalaspectsofinvasiveaspergillosis |