Teclistamab‐Induced Remission of Chronic Immune Thrombocytopenia in a Patient With Multiple Myeloma
ABSTRACT We report the case of a 76‐year‐old woman with refractory immune thrombocytopenia (ITP) and multiple myeloma (MM) who achieved remission of both conditions following teclistamab treatment. After failing multiple ITP therapies, her platelet count continued to decline. Initiation of teclistam...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | eJHaem |
| Online Access: | https://doi.org/10.1002/jha2.70062 |
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| author | Renata Quevedo‐Salazar José Miguel Yáñez‐Reyes Elías Eugenio González‐López Ana Varela‐Constantino Andrés Gómez‐De León Xitlaly Judith González‐Leal David Gómez‐Almaguer |
| author_facet | Renata Quevedo‐Salazar José Miguel Yáñez‐Reyes Elías Eugenio González‐López Ana Varela‐Constantino Andrés Gómez‐De León Xitlaly Judith González‐Leal David Gómez‐Almaguer |
| author_sort | Renata Quevedo‐Salazar |
| collection | DOAJ |
| description | ABSTRACT We report the case of a 76‐year‐old woman with refractory immune thrombocytopenia (ITP) and multiple myeloma (MM) who achieved remission of both conditions following teclistamab treatment. After failing multiple ITP therapies, her platelet count continued to decline. Initiation of teclistamab led to a rapid and sustained platelet increase, alongside MM response with measurable residual disease (MRD) negativity. Notably, remission was achieved after only four full doses, and the patient has remained in complete remission since. This case highlights teclistamab as a potential treatment for refractory ITP, suggesting a novel role for B‐cell maturation antigen (BCMA)‐targeted therapies in autoimmune diseases. Trial Registration The authors have confirmed clinical trial registration is not needed for this submission. |
| format | Article |
| id | doaj-art-43682128eb004f24a80e21de3effdb85 |
| institution | DOAJ |
| issn | 2688-6146 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj-art-43682128eb004f24a80e21de3effdb852025-08-20T03:23:08ZengWileyeJHaem2688-61462025-06-0163n/an/a10.1002/jha2.70062Teclistamab‐Induced Remission of Chronic Immune Thrombocytopenia in a Patient With Multiple MyelomaRenata Quevedo‐Salazar0José Miguel Yáñez‐Reyes1Elías Eugenio González‐López2Ana Varela‐Constantino3Andrés Gómez‐De León4Xitlaly Judith González‐Leal5David Gómez‐Almaguer6Tecnologico de Monterrey Internal Medicine, Monterrey Nuevo Leon MexicoHospital Universitario Dr. Jose Eleuterio Gonzalez Universidad Autonoma de Nuevo Leon, Hematology Monterrey Nuevo Leon MexicoClinica Gomez Almaguer, Hematology Monterrey Nuevo Leon MexicoClinica Gomez Almaguer, Hematology Monterrey Nuevo Leon MexicoClinica Gomez Almaguer, Hematology Monterrey Nuevo Leon MexicoTecnologico de Monterrey Internal Medicine, Monterrey Nuevo Leon MexicoClinica Gomez Almaguer, Hematology Monterrey Nuevo Leon MexicoABSTRACT We report the case of a 76‐year‐old woman with refractory immune thrombocytopenia (ITP) and multiple myeloma (MM) who achieved remission of both conditions following teclistamab treatment. After failing multiple ITP therapies, her platelet count continued to decline. Initiation of teclistamab led to a rapid and sustained platelet increase, alongside MM response with measurable residual disease (MRD) negativity. Notably, remission was achieved after only four full doses, and the patient has remained in complete remission since. This case highlights teclistamab as a potential treatment for refractory ITP, suggesting a novel role for B‐cell maturation antigen (BCMA)‐targeted therapies in autoimmune diseases. Trial Registration The authors have confirmed clinical trial registration is not needed for this submission.https://doi.org/10.1002/jha2.70062 |
| spellingShingle | Renata Quevedo‐Salazar José Miguel Yáñez‐Reyes Elías Eugenio González‐López Ana Varela‐Constantino Andrés Gómez‐De León Xitlaly Judith González‐Leal David Gómez‐Almaguer Teclistamab‐Induced Remission of Chronic Immune Thrombocytopenia in a Patient With Multiple Myeloma eJHaem |
| title | Teclistamab‐Induced Remission of Chronic Immune Thrombocytopenia in a Patient With Multiple Myeloma |
| title_full | Teclistamab‐Induced Remission of Chronic Immune Thrombocytopenia in a Patient With Multiple Myeloma |
| title_fullStr | Teclistamab‐Induced Remission of Chronic Immune Thrombocytopenia in a Patient With Multiple Myeloma |
| title_full_unstemmed | Teclistamab‐Induced Remission of Chronic Immune Thrombocytopenia in a Patient With Multiple Myeloma |
| title_short | Teclistamab‐Induced Remission of Chronic Immune Thrombocytopenia in a Patient With Multiple Myeloma |
| title_sort | teclistamab induced remission of chronic immune thrombocytopenia in a patient with multiple myeloma |
| url | https://doi.org/10.1002/jha2.70062 |
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